Table 1.
Twelve-Week Abstinence by Treatment
| Cardiac N = 252 |
Respiratory N = 817 |
Vascular N = 1211 |
Diabetes N = 282 |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abstinence rates by treatment | Treatment n | Abstinent n = 51 (20.24%) |
Treatment n | Abstinent n = 133 (16.28%) |
Treatment n | Abstinent n = 231 (19.08%) | Treatment n | Abstinent n = 50 (17.73%) |
|||||
| Varenicline | 60 | 24 (40.00%) | 219 | 54 (24.66%) | 302 | 88 (29.14%) | 68 | 21 (30.88%) | |||||
| Bupropion | 66 | 15 (22.73%) | 191 | 27 (14.14%) | 299 | 49 (16.39%) | 77 | 10 (12.99%) | |||||
| NRT | 70 | 10 (14.29%) | 203 | 26 (12.81%) | 313 | 63 (20.13%) | 65 | 13 (20.00%) | |||||
| Placebo | 56 | 2 (3.57%) | 204 | 26 (12.75%) | 297 | 31 (10.44%) | 72 | 6 (8.33%) | |||||
| Full model–treatment effect | Type III F (DF) | Type III F (DF) | Type III F (DF) | Type III F (DF) | |||||||||
| 6.98 (3, 244) | 5.23 (3, 809) | 11.36 (3, 1203) | 4.84 (3, 274) | ||||||||||
| Individual treatment estimates (treatment | reference) |
β | Type III F | OR (95%CI) | β | Type III F | OR (95%CI) | β | Type III F | OR (95%CI) | β | Type III F | OR (95%CI) | |
| Varenicline | Bupropion | 0.86 | 4.68 |
2.38
(1.08 to 5.25) |
0.70 | 7.23 |
2.01
(1.21 to 3.37) |
0.75 | 13.75 |
2.12
(1.42 to 3.16) |
1.20 | 7.37 |
3.35
(1.39 to 8.06) |
| NRT | 1.31 | 8.06 |
3.69
(1.48 to 9.18) |
0.84 | 10.01 |
2.31
(1.37 to 3.89) |
0.49 | 6.48 |
1.63
(1.11 to 2.37) |
0.71 | 2.60 | 2.04 (0.85 to 4.90) |
|
| Placebo | 3.15 | 16.69 |
23.29
(5.06 to 107.08) |
0.81 | 9.42 |
2.24
(1.34 to 3.76) |
1.28 | 30.86 |
3.61
(2.29 to 5.67) |
1.88 | 12.21 |
6.54
(2.26 to 18.95) |
|
| Bupropion | NRT | 0.29 | 0.36 | 1.33 (0.52 to 3.44) |
0.19 | 0.41 | 1.21 (0.66 to 2.20) |
−0.24 | 1.29 | 0.79 (0.52 to 1.19) |
−0.58 | 1.49 | 0.56 (0.22 to 3.78) |
| Placebo | 2.21 | 7.82 |
9.05
(1.91 to 42.97) |
0.11 | 0.13 | 1.12 (0.62 to 2.00) |
0.48 | 3.65 | 1.61 (0.98 to 2.62) |
0.52 | 0.85 | 1.68 (0.55 to 5.13) |
|
| NRT | Placebo | 2.82 | 7.10 |
16.84
(2.07 to 137.31) |
-0.04 | 0.02 | 0.96 (0.53 to 1.74) |
0.73 | 9.37 |
2.08
(1.30 to 3.33) |
1.17 | 4.00 |
3.23
(1.01 to 10.27) |
% abstinent represent column %s. Full models included age, race, sex, and psychiatric cohort. Italics results indicate p < .05. Additional models were run with treatment*cohort interaction term, which did not produce significant findings and thus were not reported.