Table 2.
Twenty-Four-week Abstinence by Treatment
| Cardiac N = 252 |
Respiratory N = 817 |
Vascular N = 1211 |
Diabetes N = 282 |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abstinence rates by treatment | Treatment n | Abstinent n = 29 (11.51%) |
Treatment n | Abstinent n = 83 (10.16%) |
Treatment n | Abstinent n = 154 (12.72%) |
Treatment n | Abstinent n = 31 (10.99%) |
|||||
| Varenicline | 60 | 14 (23.33%) | 219 | 30 (13.70%) | 302 | 57 (18.87) | 68 | 14 (20.59%) | |||||
| Bupropion | 66 | 9 (13.64%) | 191 | 19 (9.95%) | 299 | 36 (12.04%) | 77 | 7 (9.09%) | |||||
| NRT | 70 | 5 (7.14%) | 203 | 15 (7.39%) | 313 | 40 (12.78%) | 65 | 7 (10.77%) | |||||
| Placebo | 56 | 1 (1.79%) | 204 | 19 (9.31%) | 297 | 21 (7.07%) | 72 | 3 (4.17%) | |||||
| Full model–treatment effect | Type III F (DF) | Type III F (DF) | Type III F (DF) | Type III F (DF) | |||||||||
| 3.84 (3, 244) | 1.71 (3, 809) | 5.98 (3, 1203) | 3.76 (3, 274) | ||||||||||
| Individual treatment estimates (treatment | reference) |
β | Type III F | OR (95%CI) | β | Type III F | OR (95%CI) | β | Type III F | OR (95%CI) | β | Type III F | OR (95%CI) | |
| Varenicline | Bupropion | 0.73 | 2.34 | 2.08 (0.81 to 5.38) |
0.38 | 1.46 | 1.46 (0.78 to 2.70) |
0.55 | 5.56 |
1.73
(1.09 to 2.74) |
1.09 | 4.50 |
2.99
(1.08 to 8.32) |
| NRT | 1.35 | 5.38 |
3.86
(1.21 to 12.26) |
0.72 | 4.63 |
2.06
(1.06 to 3.98) |
0.45 | 4.04 |
1.58
(1.01 to 2.46) |
0.86 | 2.69 | 2.38 (0.84 to 6.77) |
|
| Placebo | 3.08 | 8.39 |
21.74
(2.65 to 178.23) |
0.44 | 1.98 | 1.55 (0.84 to 2.89) |
1.12 | 17.00 |
3.08
(1.80 to 5.25) |
2.13 | 9.28 |
8.43
(2.11 to 33.65) |
|
| Bupropion | NRT | 0.36 | 0.35 | 1.44 (0.43 to 4.89) |
0.44 | 1.43 | 1.55 (0.75 to 3.21) |
−0.07 | 0.07 | 0.94 (0.58 to 1.52) |
−0.23 | 0.16 | 0.79 (0.25 to 2.52) |
| Placebo | 2.34 | 4.59 |
10.40
(1.19 to 90.36) |
0.06 | 0.04 | 1.07 (0.54 to 2.11) |
0.54 | 3.38 | 1.71 (0.96 to 3.03) |
0.62 | 0.70 | 1.86 (0.43 to 8.13) |
|
| NRT | Placebo | 2.24 | 3.12 | 9.36 (0.76 to 114.93) |
−0.32 | 0.77 | 0.72 (0.35 to 1.49) |
0.62 | 4.76 |
1.87
(1.06 to 3.27) |
1.28 | 2.60 | 3.62 (0.75 to 17.52) |
% abstinent represent column %s. Full models included age, race, sex, and psychiatric cohort. Italics results indicate p < .05. Additional models were run with treatment*cohort interaction term, which did not produce significant findings and thus were not reported.