TABLE 1.

Clinical comprehensive diagnostic criteria

It fits both 1 and 2, and then it fits any of 3 or 4
1. Clinical signs (consistent with any point)	Changes in consciousness and mental state: new delirium, irritability, lethargy, and coma. Increased intracranial pressure: headache, vomiting, and papilledema. Meningeal stimulation signs: cervical stiffness, Kernig sign (+), and Brudzinski sign (+). Symptoms of systemic infection: T > 38°C or T < 36°C, increased heart rate and respiration.
2. Cerebrospinal fluid examination results	Intracranial pressure > 200 mmH2O. The character of cerebrospinal fluid is cloudy, yellow, or purulent. Cerebrospinal fluid leukocyte > 1,000/mm3 and polynuclear leukocyte > 70%. Glucose < 2.2 mmol/L and cerebrospinal fluid glucose content/serum glucose content ≤ 0.4.
3. Clinical imaging examination	Computed tomography/magnetic resonance imaging: diffuse intracerebral edema, dural thickening and enhancement, or dilation of the ventricular system, or even typical annular enhanced space occupying.
4. Blood routine	Leukocyte > 10*109 /L, neutrophil ratio more than 80%.