TABLE 1.
Genes associated with non-β-lactam resistance of S. saprophyticus in the present work
| ARG | Annotation | Isolate numbera | Non-susceptible rateb | Associated AMR | Reference of the ARG reported in other CoNS |
|---|---|---|---|---|---|
| tet(K) | Tetracycline efflux MFSd transporter | 25 | 88.0% | Doxycycline | Reference (58) |
| dfrG | Trimethoprim-resistant dihydrofolate reductase | 14 | 35.7% | TMP-SMX | Reference (59) |
| dfrC | Trimethoprim-resistant dihydrofolate reductase | 12 | 41.7% | TMP-SMX | References (60, 61) |
| folA_2 | Dihydrofolate reductase | 6 | 50.0% | TMP-SMX | References (62, 63) |
| msr(A) | ABC-F type ribosomal protection protein | 20 | 100.0% | Erythromycin | References (64, 65) |
| mph(C)c | Mph(C) family macrolide 2'-phosphotransferase | 72 | 98.6% | Erythromycin | References (55, 56) |
| erm | 23S ribosomal RNA methyltransferase | 18 | 94.4% | Erythromycin | Reference (66) |
| erm (44)v | 23S rRNA (adenine(2058)-N (6))-methyltransferase | 14 | 100.0%, 92.9%, and 100.0% |
Erythromycin, Clindamycin, ICR |
Reference (67) |
| erm(C) | 23S rRNA (adenine(2058)-N (6))-methyltransferase | 6 | 100.0%, 50.0%, and 100.0% |
Erythromycin, Clindamycin, ICR |
References (56, 68) |
| abc-f | ABC-F type ribosomal protection protein | 10 | 100.0% | Clindamycin | Reference (69) |
a
The number of isolates carrying the ARG.
b
The ratio of the number of isolates showed phenotypic non-susceptibility to the number of isolates carrying the ARG.
c
mph(C) occurred only in combination with msr(A) in the present study.
d
Major Facilitator Superfamily.