Fig 9.

CID1067700 inhibits PHEV neural transmission in CNS. (A) Schematic diagrams illustrating the experimental design for time-of-drug treatment and sacrifice experiments. (B) Mice were monitored daily for body weight change in different groups. (C) PHEV N genomic RNA levels in DMSO- or CID1067700-treated PHEV-infected mice. (D) PHEV N protein and LAMP1 levels in DMSO- or CID1067700-treated PHEV-infected mice. (E)Colocalization of PHEV and LAMP1 in mice brain sections. DMSO- or CID1067700-treated PHEV-infected brain sections were immunostained with anti-LAMP1 (red) and anti-PHEV (green) antibodies. Representative blots and images are shown. Data are shown as mean ± SD. P values were considered significant when P < 0.05 and denoted as, **, P < 0.01 and ***, P < 0.001.