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. 2022 Nov 11;16(12):639–650. doi: 10.1161/CIRCEP.123.012567

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© 2023 The Authors.

Circulation: Arrhythmia and Electrophysiology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Study design. ReVeRA (Reduction of Ventricular Rate in Patients with Atrial Fibrillation) phase 2, multicenter, randomized, double-blind, placebo-controlled study for evaluating the efficacy and safety of etripamil nasal spray (NS) administered intranasally to patients presenting to an emergency department (ED) with atrial fibrillation-rapid ventricular rate (AF-RVR). BP indicates blood pressure; bpm, beats per minute; HR, heart rate.