Table 5.
The signaling pathway of KEGG enrichment target number ≥ 20.
| GO | Pathway | Count | Genes |
|---|---|---|---|
| hsa05200 | Pathways in cancer | 65 | AKT1 XIAP BIRC5 AR BAX CCND1 BCL2 BCL2L1 CASP3 CASP7 CASP8 CASP9 CCNA2 CDK2 CDK4 CDKN1A CDKN2A CHUK NQO1 E2F1 E2F2 EGF EGFR ELK1 ERBB2 ESR1 ESR2 FN1 FOS GSK3B GSTM1 GSTP1 HIF1A HMOX1 IFNG IGF2 IL2 IL4 IL6 CXCL8 JUN MDM2 MET MMP1 MMP2 MMP9 MYC NFE2L2 NFKBIA NOS2 PPARG PRKACA PRKCA MAPK1 PTEN PTGS2 RAF1 RB1 RELA STAT1 TGFB1 TP53 VEGFA RASSF1 CYCS |
| hsa05417 | Lipid and atherosclerosis | 36 | AKT1 BAX BCL2 BCL2L1 CASP3 CASP7 CASP8 CASP9 CD40LG CHUK MAPK14 CYP1A1 FOS GSK3B HSPA5 ICAM1 IL1B IL6 CXCL8 JUN MMP1 MMP3 MMP9 NFATC1 NFE2L2 NFKBIA NOS3 PPARG PRKCA MAPK1 RELA CCL2 TNF TP53 VCAM1 CYCS |
| hsa05163 | Human cytomegalovirus infection | 35 | AKT1 BAX CCND1 CASP3 CASP8 CASP9 CDK4 CDKN1A CDKN2A CHUK MAPK14 E2F1 E2F2 EGFR ELK1 GSK3B IL1B IL6 CXCL8 MDM2 MYC NFATC1 NFKBIA PRKACA PRKCA MAPK1 PTGS2 RAF1 RB1 RELA CCL2 TNF TP53 VEGFA CYCS |
| hsa04151 | PI3K-Akt signaling pathway | 35 | AKT1 CCND1 BCL2 BCL2L1 CASP9 CDK2 CDK4 CDKN1A CHUK EGF EGFR ERBB2 ERBB3 FN1 GSK3B IGF2 IL2 IL4 IL6 INSR KDR MCL1 MDM2 MET MYC NOS3 PIK3CG PRKCA MAPK1 PTEN RAF1 RELA SPP1 TP53 VEGFA |
| hsa05161 | Hepatitis B | 34 | AKT1 BIRC5 BAX BCL2 CASP3 CASP8 CASP9 CCNA2 CDK2 CDKN1A CHUK MAPK14 E2F1 E2F2 ELK1 FOS IL6 CXCL8 JUN MMP9 MYC NFATC1 NFKBIA PCNA PRKCA MAPK1 RAF1 RB1 RELA STAT1 TGFB1 TNF TP53 CYCS |
| hsa05166 | Human T-cell leukemia virus 1 infection | 33 | AKT1 XIAP BAX CCND1 BCL2L1 CCNA2 CDK2 CDK4 CDKN1A CDKN2A CHEK1 CHUK E2F1 E2F2 ELK1 FOS ICAM1 IL2 IL6 JUN MYC NFATC1 NFKBIA PRKACA MAPK1 PTEN RB1 RELA TGFB1 TNF TP53 FOSL1 CHEK2 |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 32 | AKT1 BAX CCND1 CASP3 CASP8 CASP9 CDK4 CDKN1A CHUK MAPK14 E2F1 E2F2 FOS GSK3B HIF1A ICAM1 IL6 CXCL8 JUN MYC NFATC1 NFKBIA PIK3CG MAPK1 PTGS2 RAF1 RB1 RELA STAT1 TP53 VEGFA CYCS |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 30 | AKT1 BAX CCND1 BCL2 CASP3 CDK4 MAPK14 F3 FN1 ICAM1 IL1A IL1B IL6 CXCL8 JUN MMP2 NFATC1 NOS3 SERPINE1 PRKCA PRKCD MAPK1 RELA CCL2 STAT1 TGFB1 THBD TNF VCAM1 VEGFA |
| hsa04218 | Cellular senescence | 29 | AKT1 CCND1 CCNA2 CCNB1 CDK1 CDK2 CDK4 CDKN1A CDKN2A CHEK1 MAPK14 E2F1 E2F2 IGFBP3 IL1A IL6 CXCL8 MDM2 MYC NFATC1 SERPINE1 MAPK1 PTEN RAF1 RB1 RELA TGFB1 TP53 CHEK2 |
| hsa05205 | Proteoglycans in cancer | 29 | AKT1 CCND1 CASP3 CAV1 CDKN1A MAPK14 EGFR ELK1 ERBB2 ERBB3 ESR1 FN1 HIF1A IGF2 KDR MDM2 MET MMP2 MMP9 MYC PLAU PRKACA PRKCA MAPK1 RAF1 TGFB1 TNF TP53 VEGFA |
| hsa04010 | MAPK signaling pathway | 29 | AKT1 CASP3 CHUK MAPK14 EGF EGFR ELK1 ERBB2 ERBB3 FOS HSPB1 IGF2 IL1A IL1B INSR JUN KDR MET MYC NFATC1 PRKACA PRKCA MAPK1 RAF1 RELA TGFB1 TNF TP53 VEGFA |
| hsa05165 | Human papillomavirus infection | 29 | AKT1 BAX CCND1 CASP3 CASP8 CCNA2 CDK2 CDK4 CDKN1A CHUK E2F1 EGF EGFR FN1 GSK3B IRF1 MDM2 PRKACA MAPK1 PTEN PTGS2 RAF1 RB1 RELA SPP1 STAT1 TNF TP53 VEGFA |
| hsa05207 | Chemical carcinogenesis - receptor activation | 28 | AHR AKT1 XIAP BIRC5 AR CCND1 BCL2 CYP1A1 CYP1A2 CYP1B1 CYP3A4 E2F1 EGF EGFR ESR1 ESR2 FOS GSTM1 JUN MYC PGR PRKACA PRKCA MAPK1 RAF1 RB1 RELA VEGFA |
| hsa05418 | Fluid shear stress and atherosclerosis | 27 | AKT1 BCL2 CAV1 CHUK MAPK14 NQO1 FOS GSTM1 GSTP1 HMOX1 ICAM1 IFNG IL1A IL1B JUN KDR MMP2 MMP9 NFE2L2 NOS3 RELA CCL2 THBD TNF TP53 VCAM1 VEGFA |
| hsa05160 | Hepatitis C | 27 | AKT1 BAX CCND1 CASP3 CASP8 CASP9 CDK2 CDK4 CDKN1A CHUK CLDN4 E2F1 E2F2 EGF EGFR GSK3B IFNG MYC NFKBIA MAPK1 RAF1 RB1 RELA STAT1 TNF TP53 CYCS |
| hsa05225 | Hepatocellular carcinoma | 27 | AKT1 BAX CCND1 BCL2L1 CDK4 CDKN1A CDKN2A NQO1 E2F1 E2F2 EGFR ELK1 GSK3B GSTM1 GSTP1 HMOX1 IGF2 MET MYC NFE2L2 PRKCA MAPK1 PTEN RAF1 RB1 TGFB1 TP53 |
| hsa05169 | Epstein-Barr virus infection | 27 | AKT1 BAX CCND1 BCL2 CASP3 CASP8 CASP9 CCNA2 CDK2 CDK4 CDKN1A CHUK MAPK14 E2F1 E2F2 ICAM1 IL6 JUN MDM2 MYC NFKBIA RB1 RELA STAT1 TNF TP53 CYCS |
| hsa05215 | Prostate cancer | 26 | AKT1 AR CCND1 BCL2 CASP9 CDK2 CDKN1A CHUK E2F1 E2F2 EGF EGFR ERBB2 GSK3B GSTP1 MDM2 MMP3 MMP9 NFKBIA PLAU MAPK1 PTEN RAF1 RB1 RELA TP53 |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species | 26 | AHR AKT1 CHUK MAPK14 CYP1A1 CYP1A2 CYP1B1 NQO1 EGF EGFR FOS GSTM1 HIF1A HMOX1 JUN MET NFE2L2 NFKBIA PRKCD MAPK1 PTEN PTPN1 RAF1 RELA SOD1 VEGFA |
| hsa05206 | MicroRNAs in cancer | 26 | CCND1 BCL2 CASP3 CDKN1A CDKN2A CYP1B1 E2F1 E2F2 EGFR ERBB2 ERBB3 HMOX1 MCL1 MDM2 MET MMP9 MYC PLAU PRKCA MAPK1 PTEN PTGS2 RAF1 TP53 VEGFA RASSF1 |
| hsa05222 | Small cell lung cancer | 24 | AKT1 XIAP BAX CCND1 BCL2 BCL2L1 CASP3 CASP9 CDK2 CDK4 CDKN1A CHUK E2F1 E2F2 FN1 MYC NFKBIA NOS2 PTEN PTGS2 RB1 RELA TP53 CYCS |
| hsa01522 | Endocrine resistance | 24 | AKT1 BAX CCND1 BCL2 CDK4 CDKN1A CDKN2A MAPK14 E2F1 E2F2 EGFR ERBB2 ESR1 ESR2 FOS JUN MDM2 MMP2 MMP9 PRKACA MAPK1 RAF1 RB1 TP53 |
| hsa04210 | Apoptosis | 23 | PARP1 AKT1 XIAP BIRC5 BAX BCL2 BCL2L1 CASP3 CASP7 CASP8 CASP9 CHUK CTSD FOS JUN MCL1 NFKBIA MAPK1 RAF1 RELA TNF TP53 CYCS |
| hsa05162 | Measles | 23 | AKT1 BAX CCND1 BCL2 BCL2L1 CASP3 CASP8 CASP9 CDK2 CDK4 CHUK FOS GSK3B IL1A IL1B IL2 IL6 JUN NFKBIA RELA STAT1 TP53 CYCS |
| hsa05164 | Influenza A | 23 | AKT1 BAX CASP3 CASP8 CASP9 CDK4 CHUK ICAM1 IFNG IL1A IL1B IL6 CXCL8 NFKBIA PRKCA MAPK1 PRSS1 RAF1 RELA CCL2 STAT1 TNF CYCS |
| hsa05212 | Pancreatic cancer | 22 | AKT1 BAX CCND1 BCL2L1 CASP9 CDK4 CDKN1A CDKN2A CHUK E2F1 E2F2 EGF EGFR ERBB2 MAPK1 RAF1 RB1 RELA STAT1 TGFB1 TP53 VEGFA |
| hsa04657 | IL-17 signaling pathway | 22 | CASP3 CASP8 CHUK MAPK14 FOS GSK3B IFNG IL1B IL4 IL6 CXCL8 JUN MMP1 MMP3 MMP9 NFKBIA MAPK1 PTGS2 RELA CCL2 TNF FOSL1 |
| hsa05145 | Toxoplasmosis | 22 | AKT1 ALOX5 XIAP BCL2 BCL2L1 CASP3 CASP8 CASP9 CD40LG CHUK MAPK14 IFNG IL10 NFKBIA NOS2 PIK3CG MAPK1 RELA STAT1 TGFB1 TNF CYCS |
| hsa05224 | Breast cancer | 22 | AKT1 BAX CCND1 CDK4 CDKN1A E2F1 E2F2 EGF EGFR ERBB2 ESR1 ESR2 FOS GSK3B JUN MYC PGR MAPK1 PTEN RAF1 RB1 TP53 |
| hsa05170 | Human immunodeficiency virus 1 infection | 22 | AKT1 BAX BCL2 BCL2L1 CASP3 CASP8 CASP9 CCNB1 CDK1 CHEK1 CHUK MAPK14 FOS JUN NFATC1 NFKBIA PRKCA MAPK1 RAF1 RELA TNF CYCS |
| hsa05022 | Pathways of neurodegeneration - multiple diseases | 22 | BAX BCL2 BCL2L1 CASP3 CASP7 CASP8 CASP9 MAPK14 GSK3B HSPA5 IL1A IL1B IL6 NOS2 PRKCA MAPK1 PTGS2 RAF1 RELA SOD1 TNF CYCS |
| hsa05219 | Bladder cancer | 21 | CCND1 CDK4 CDKN1A CDKN2A E2F1 E2F2 EGF EGFR ERBB2 CXCL8 MDM2 MMP1 MMP2 MMP9 MYC MAPK1 RAF1 RB1 TP53 VEGFA RASSF1 |
| hsa04115 | p53 signaling pathway | 21 | BAX CCND1 BCL2 BCL2L1 CASP3 CASP8 CASP9 CCNB1 CDK1 CDK2 CDK4 CDKN1A CDKN2A CHEK1 IGFBP3 MDM2 SERPINE1 PTEN TP53 CHEK2 CYCS |
| hsa04668 | TNF signaling pathway | 21 | AKT1 CASP3 CASP7 CASP8 CHUK MAPK14 FOS ICAM1 IL1B IL6 IRF1 JUN MMP3 MMP9 NFKBIA MAPK1 PTGS2 RELA CCL2 TNF VCAM1 |
| hsa05152 | Tuberculosis | 21 | AKT1 BAX BCL2 CASP3 CASP8 CASP9 MAPK14 CTSD IFNG IL1A IL1B IL6 IL10 NOS2 MAPK1 RAF1 RELA STAT1 TGFB1 TNF CYCS |
| hsa05132 | Salmonella infection | 21 | AKT1 BAX BCL2 CASP3 CASP7 CASP8 CHUK MAPK14 FOS IL1B IL6 CXCL8 JUN MYC NFKBIA PIK3CG MAPK1 RAF1 RELA TNF CYCS |
| hsa05142 | Chagas disease | 20 | AKT1 CASP8 CHUK MAPK14 FOS IFNG IL1B IL2 IL6 CXCL8 IL10 JUN NFKBIA NOS2 SERPINE1 MAPK1 RELA CCL2 TGFB1 TNF |
| hsa04625 | C-type lectin receptor signaling pathway | 20 | AKT1 CASP8 CHUK MAPK14 IL1B IL2 IL6 IL10 IRF1 JUN MDM2 NFATC1 NFKBIA PRKCD MAPK1 PTGS2 RAF1 RELA STAT1 TNF |
| hsa04510 | Focal adhesion | 20 | AKT1 XIAP CCND1 BCL2 CAV1 EGF EGFR ELK1 ERBB2 FN1 GSK3B JUN KDR MET PRKCA MAPK1 PTEN RAF1 SPP1 VEGFA |
| hsa05131 | Shigellosis | 20 | AKT1 BAX BCL2 BCL2L1 CHUK MAPK14 EGFR GSK3B HK2 IL1B CXCL8 JUN MDM2 NFKBIA PRKCD MAPK1 RELA TNF TP53 CYCS |