TABLE 5.

Analysis of the Prognostic Factors Using Cox Proportional Hazard Analysis in Groups D and E

Factor	Object	Control	Univariate Analysis		Multivariate Analysis
			Hazard Ratio (95% CI)	P	Hazard Ratio (95% CI)	P
Age (years)	<75	≥75	0.692 (0.460–1.023)	0.065
Sex	Male	Female	1.137 (0.761–1.700)	0.395
Location of the tumor	Ce/Ut	Mt/Lt	1.380 (1.015–1.877)	0.039	1.293 (0.865–1.934)	0.271
Depth of invasion	T0/1/2	T3/T4	0.334 (0.245–0.454)	<0.0001	0.421 (0.286–0.619)	<0.0001
Lymph node metastasis	Negative	Positive	0.314 (0.232–0.424)	<0.0001	0.381 (0.286–0.556)	<0.0001
Extent of lymphadenectomy	2-field	3-field	0.957 (0.711–1.289)	0.774
Resectability	R0	R1 or R2	0.264 (0.180–0.386)	<0.0001	0.477 (0.316–0.721)	0.0004
Pulmonary complications	None	Present	0.787 (0.468–1.161)	0.189
Anastomotic leakage	None	Present	0.922 (0.624–1.363)	0.687

CI, confidence interval; Ce, cervical; Ut, upper thoracic; Mt, middle thoracic; Lt, lower thoracic; T, tumor.