TABLE 2.
Characteristics of Patients with EGD vs. no EGD in Derivation Cohort A
| Early Graft Dysfunction | |||
|---|---|---|---|
| Preoperative Characteristics | Yes (n = 92) | No (n = 182) | P |
| Recipient age (years) Gender (male, %) BMI |
46 ± 9.6 85 (92.4) 26.57 ± 5.2 |
47.7 ± 9.4 160 (87.9) 25.32 ± 4.6 |
0.15 0.25 0.10 |
| Donor age (years) Gender (male, %) Liver attenuation index Steatotic graft |
35.6 ± 9.5 40 (43.5) 9.84 ± 5.67 12 (13) |
29.9 ± 8.9 75 (41.2) 10.67 ± 5.05 15 (8.2) |
0.02 0.71 0.34 0.21 |
| MELD score at transplant | 24.9 ± 5.4 | 21.8 ± 5.7 | <0.001 |
| Child-Pugh status | |||
| A (%) | 0 (0.0) | 2 (1.1) | 0.36 |
| B (%) C (%) |
10 (10.9) 82 (89.1) |
25 (13.7) 155 (85.2) |
|
| Co-morbidities (%) | 41 (44.5) | 90 (49.4) | 0.52 |
| Chronic liver disease (%) ACLF (%) |
78 (84.7) 14 (15.3) |
163 (89.6) 19 (10.4) |
0.19 |
| Etiology (%) | |||
| Alcohol | 45 (48.9) | 85 (46.7) | 0.44 |
| Cryptogenic HBV HCV NASH Others |
14 (15.2) 7 (7.6) 5 (5.4) 12 (13) 9 (9.7) |
22 (12.1) 17 (9.3) 12 (6.5) 30 (16.5) 16 (8.9) |
|
| Estimated graft weight(grams) | 653.3 ± 124.71 | 692.79 ± 119.21 | 0.011 |
| GRWR (%) | 0.86 ± 0.24 | 0.92 ± 0.22 | 0.013 |
| Intraoperative parameters | |||
| Anhepatic phase (min) | 142 ± 46.2 | 136 ± 43.2 | 0.29 |
| Cold ischemia time (min) | 99 ± 33.1 | 97 ± 30 | 0.74 |
| Warm ischemia time (min) | 31.9 ± 9.1 | 31 ± 11.8 | 0.56 |
| Graft type (%) | 0.08 | ||
| Right Left |
73 (79.3) 19 (20.7) |
159 (87.4) 23 (12.6) |
|
| Presence of PVT (%) | 12 (13) | 24 (13.2) | 0.97 |
| Portal venous flow (L/min) | 2.9 ± 1.1 | 2.6 ± 1.1 | 0.06 |
| Blood loss (mL) | 2961 ± 1794 | 2484 ± 1391 | 0.01 |
| Postoperative parameters | |||
| Peak INR | 4.6 ± 1.4 | 3.8 ± 1.4 | <0.001 |
| Peak serum creatinine(mg/dL) | 1.5 ± 0.6 | 1.1 ± 0.6 | <0.001 |
| Peak T. bilirubin (mg/dL) | 13.7 ± 9.2 | 8.3 ± 4.7 | < 0.001 |
| Peak AST (IU/L) | 154.9 ± 111 | 59.3 ± 38.9 | <0.001 |
| Peak ALT (IU/L) | 116.2 ± 59.2 | 95.9 ± 83.2 | <0.001 |
| Ascites >1 L on day 14(%) | 41 (44.5) | 44 (24.1) | <0.001 |
| Bacterial sepsis (%) | 48 (52.1) | 53 (29.1) | <0.001 |
| Hospital stay (days) | 30.3 ± 23.8 | 24.4 ± 15.3 | 0.014 |
| ICU/HDU stay (days) | 19 ± 37.6 | 11 ± 11.3 | <0.001 |
| Retransfer to ICU (%) | 17 (21.7) | 18 (9.8) | 0.01 |
| Morbidity (CDC ≥IIIa) (%) | 44 (47.8) | 68 (37.3) | 0.009 |
| 30-day mortality (%) | 16 (17.3) | 7 (3.8) | <0.001 |
ACLF = acute on chronic liver failure; ALT = alanine transaminase; AST = aspirate transaminase; BMI = steatotic graft; CDC = Clavein-Dindo classification; GRWR = graft-to-recipient weight ratio; HBV = hepatitis B virus; HCV = hepatitis C virus; HDU = high dependency unit; ICU = intensive care unit; INR = international normalized ratio; MELD = model for end-stage liver disease; NASH = nonalcoholic steatohepatitis; PVT = portal vein thrombosis.