Table 2.
A summary of drugs suspected of causing DILI.
| Highly probable drug and HDS association (n = 18) | Possible drug association (n = 4) | Reported but unproven (n = 21) | Reported only in the 1970s and 1980s (n = 15) |
|---|---|---|---|
| Nitrofurantoin14 | Etanercept21 | Cephalexin14 | Halothane4 |
| Minocycline14 | Efalizumab21 | Clometacine4 | Tienilic cacid4 |
| Methyldopa20 | Atovaquone/Proguanil84 | Echinacea4 | Oxiphensation4 |
| Hydralazine20 | Turmeric21 | Pemoline4 | Sulfonamide4 |
| Infliximab35 | Ma Huang21 | Propylthiouracil4 | |
| Interferon-α & β 21 | Prometrium14 | Isoniazid4 | |
| Atorvastatin20 | Hydroxycut4 | Dantrolene4 | |
| Simvastatin20 | Meloxicam4 | Perhexiline maleate4 | |
| Fluvastatin20 | Methotrexate4 | Amiodarone4 | |
| Rosuvastatin20 | N-Nitroso-fenfluramine4 | Papaverine4 | |
| Imatinib21 | Ambrisentan4 | Benzarone4 | |
| Masitinib21 | Glucosamine/chondroitin sulfate4 | Terbinafine4 | |
| Adalimumab21 | Camostat/benzbromarone4 | Methylphenidate4 | |
| Diclofenac21 | Xiang-tian-guo4 | Bupropion4 | |
| Methylprednisolone21 | Indometacin4 | Olmesartan4 | |
| Cyproterone4 | Varenicline21 | ||
| Khat21 | Menotrophin21 | ||
| Tinospora cordifola21,83 | Indometacin4 | ||
| Fenofibrate4 | |||
| Pazopanib4 | |||
| Phenprocoumon4 |
Drugs with well documented DI-ALH (strong association), with convincing reports, that have been analysed and undergone causality assessment; possible DI-ALH with several reports that suggest a relationship but do not fulfil criteria proposed in a recent paper on DI-ALH,24 those that have been reported, mostly in single reports, with short follow-up and/or important clinical information lacking. Finally, drugs suspected to have induced DI-ALH but only in the 1970s and 1980s, before the detection of hepatitis C and with competing causes often not excluded. References are in parentheses.