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. Author manuscript; available in PMC: 2023 Dec 21.
Published in final edited form as: Osteoarthritis Cartilage. 2021 Sep 14;30(2):184–195. doi: 10.1016/j.joca.2021.04.020

Table II.

Person- and joint-level factors with evidence for impacting risk for developing OA

Person-Level Factors Joint-Level Factors
Age Joint Injury
Sex Joint malalignment (Mixed evidence)
Race/Ethnicity Joint Deformity/Abnormal Joint Shape
Socioeconomic Status Muscle Weakness (Mixed evidence)
Rural Residence Leg length Inequality
Family History and Genetic Factors Physically Demanding Occupational Tasks
Obesity Elite sports
High Blood Pressure (Mixed evidence)
High Bone Mineral Density
Metformin Use