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. 2023 Aug 7;25(1):95–104. doi: 10.1093/ehjci/jead188

Table 1.

Baseline and follow-up characteristics of the complete cardiac amyloidosis cohort

Variable Baseline Follow-up P value
(n = 103) (n = 103)
Clinical parameters
Age, years 75.0 (68.0–79.0) 77.0 (70.0–81.0) <0.001
Sex, male gender, n 82 (79.6) 82 (79.6) 1.000
NYHA functional class ≥ III, n 36 (35.0) 25 (24.3) 0.054
6-min walk test, m 400 (296–480) 402 (323–486) 0.858
N-terminal pro brain natriuretic peptide, pg/mL 1917 (787–3542) 2222 (810–3502) 0.400
Troponin T, ng/mL 0.043 (0.029–0.065) 0.051 (0.028–0.071) 0.093
eGFR, mL/min/1.73m2 56.5 (42.4–75.0) 54.0 (43.0–68.7) 0.019
Cardiac magnetic resonance imaging parameters
Myocardial native T1 time, ms 1099 (1057–1139) 1107 (1077–1144) 0.006
Individual change of myocardial T1 time, % +12.0 (−17.5 to +36.3) n.a
Extracellular volume, % 48.0 (40.0–55.3) 50.5 (43.1–59.5) <0.001
Individual change of extracellular volume, % +3.5 (−1.9 to +6.9) n.a
Interventricular septum, mm 18.0 (15.0–21.0) 18.4 (16.0–22.0) 0.695
Left ventricular mass, g 194 (154–229) 195 (150–231) 0.449
Left atrial area, cm2 31.0 (26.0–37.0) 32.0 (28.0–36.0) 0.591
Right atrial area, cm2 30.0 (25.0–36.0) 30.0 (26.8–35.0) 0.241
Left ventricular global longitudinal strain, % −12.6 (−15.3 to −10.1) −12.3 (−15.4 to −9.5) 0.348
Left ventricular ejection fraction, % 56.0 (47.0–62.0) 50.6 (45.0–60.0) 0.009
Left ventricular cardiac output, L/min 5.7 (4.9–6.5) 5.8 (4.9–6.4) 0.829
Left ventricular end-diastolic volume, mL 159 (139–189) 166 (150–205) <0.001
Right ventricular ejection fraction, % 49.0 (41.0–58.0) 45.9 (39.0–53.0) <0.001
Right ventricular cardiac output, L/min 5.3 (4.5–6.4) 5.3 (4.4–6.3) 0.745
Right ventricular end-diastolic volume, mL 171 (142–191) 177 (154–209) <0.001
Pulmonary artery, mm 28.0 (25.0–31.0) 28.0 (25.0–31.0) 0.786
Pleural effusion, n 28 (27.2) 35 (34.0) 0.189
Pericardial effusion, n 43 (41.7) 44 (42.7) 1.000

NYHA, New York Heart Association; eGFR, estimated glomerular filtration rate; n.a, not applicable. Numbers in brackets are % for dichotomous and IQR for continuous variables.

Magnetic resonance imaging. T0 was date of follow-up CMR.