Table 2.

Cox regression analyses (Model A) for the composite endpoint of all-cause death or heart failure hospitalization in the total, transthyretin, and light chain cardiac amyloidosis cohorts

Variable	Crude hazard ratio	95% Confidence interval	P value	Adjusted hazard ratio	95% Confidence interval	P value	Adjusted hazard ratio	95% Confidence interval	P value
	Univariable regression			Multivariable regression 1			Multivariable regression 2
Cardiac magnetic resonance imaging parameters
Total cardiac amyloidosis cohort
Baseline native T1 timea	1.006	0.999–1.012	0.113	1.008	1.000–1.015	0.0448	n.a
Follow-up native T1 timeb	1.004	0.999–1.009	0.155	1.004	0.999–1.010	0.094	1.003	0.998–1.009	0.268
Change of native T1 timeb	1.003	0.996–1.009	0.396	1.002	0.996–1.009	0.466	1.003	0.996–1.010	0.470
Baseline extracellular volumea	1.027	0.998–1.057	0.071	1.027	0.996–1.060	0.093	n.a
Follow-up extracellular volumeb	1.024	1.003–1.045	0.026	1.028	1.006–1.051	0.013	1.020	0.996–1.045	0.110
Change of extracellular volumeb	1.085	1.041–1.130	<0.001	1.113	1.063–1.166	<0.001	1.095	1.047–1.145	<0.001
Cardiac transthyretin amyloidosis cohort
Baseline native T1 timea	1.004	0.995–1.013	0.373	1.004	0.994–1.014	0.423	n.a
Follow-up native T1 timeb	1.002	0.995–1.009	0.517	1.004	0.997–1.012	0.240	1.002	0.994–1.010	0.673
Change of native T1 timeb	1.004	0.995–1.013	0.358	1.007	0.997–1.017	0.179	1.006	0.996–1.016	0.267
Baseline extracellular volumea	1.030	0.993–1.067	0.114	1.026	0.987–1.065	0.193	n.a
Follow-up extracellular volumeb	1.015	0.990–1.040	0.240	1.020	0.994–1.046	0.128	1.004	0.974–1.036	0.775
Change of extracellular volumeb	1.066	1.015–1.119	0.010	1.094	1.037–1.153	<0.001	1.073	1.015–1.134	0.013
Cardiac light chain amyloidosis cohort
Baseline native T1 timea	1.006	0.996–1.016	0.217	1.008	0.995–1.020	0.235	n.a
Follow-up native T1 timeb	1.004	0.997–1.012	0.248	1.002	0.992–1.011	0.755	1.004	0.994–1.013	0.437
Change of native T1 timeb	1.004	0.994–1.014	0.439	0.997	0.985–1.009	0.621	1.000	0.988–1.011	0.959
Baseline extracellular volumea	1.019	0.958–1.084	0.557	1.001	0.923–1.085	0.984	n.a
Follow-up extracellular volumeb	1.065	1.006–1.126	0.030	1.089	0.987–1.202	0.090	1.133	1.015–1.265	0.026
Change of extracellular volumeb	1.110	1.033–1.193	0.004	1.114	1.020–1.217	0.017	1.131	1.041–1.228	0.003

Multivariable Model 1: Adjusted for baseline NT-proBNP, troponin T, and time interval between baseline and follow-up cardiac magnetic resonance (CMR) imaging.

Multivariable Model 2: Adjusted for follow-up NT-proBNP, follow-up troponin T, and time interval between baseline and follow-up cardiac magnetic resonance imaging.

^aStart date for the follow-up period (T0) is the date of baseline CMR.

^bT0 was date of follow-up CMR.