Table 3.
Characteristics of subset of patients and healthy controls (n = 50/group)a
| Pre-opb | Post-opb | P valuec | Control (CTL) | Adjusted P value (pre-op vs CTL)d | |
|---|---|---|---|---|---|
| Age, years | 79 ± 8 (59-98) | 66 ± 3 (60-75) | <.001 | ||
| BMI, kg/m2 | 24.8 ± 4.9 | 27.7 ± 2.4 | <.001 | ||
| Albumin, g/dL | 3.6 ± 0.6 | 2.9 ± 0.5 | <.001 | 4.5 ± 0.3 | <.001 |
| DBP, mg/dL | 32.1 ± 7.0 | 29.3 ± 5.6 | .003 | 39.4 ± 5.1 | <.001 |
| Total 25OHD, ng/mL | 21.8 ± 10.7 | 18.8 ± 8.6 | <.001 | 29.7 ± 7.8 | <.001 |
| Free 25OHD, pg/mL | 5.5 ± 2.1 | 5.2 ± 2.2 | .011 | 5.9 ± 1.7 | .637 |
| Bioavailable 25OHD, ng/mL | 1.5 ± 0.9 | 1.2 ± 0.6 | <.001 | 2.0 ± 0.4 | .035 |
| iPTH, pg/mL | 52.3 ± 32.4 | 61.9 ± 39.5 | .043 | 38.9 ± 23.9 | .013 |
| IL-6, pg/mL | 58.7 ± 52.4 | 154.9 ± 136.4 | <.001 | 2.1 ± 2.0 | <.001 |
| CRP, mg/L | 11.5 ± 12.7 | 20.2 ± 8.3 | <.001 | 2.6 ± 2.3 | <.001 |
| TNF-alpha, pg/mL | 22.2 ± 35.5 | 25.7 ± 31.8 | .060 | 12.1 ± 13.4 | .631 |
| F-actin, ng/mL | 6.5 ± 4.8 | 4.9 ± 4.5 | <.001 | 0.7 ± 0.9 | <.001 |
| Gelsolin, mg/L | 119.3 ± 51.7 | 80.1 ± 41.1 | <.001 | 175.0 ± 40.3 | <.001 |
Values of DBP, free and total 25OHD, and albumin in the subset did not differ significantly (P > .10) compared to the larger patient population (n = 260; Table 1).
Abbreviations: CTL, control; CRP, C-reactive protein; DBP, vitamin D binding protein; iPTH, intact parathyroid hormone; IL-6, interleukin-6; pre-op, preoperative; post-op, postoperative; TNF-alpha, tumor necrosis factor alpha; 25OHD, 25-hydroxyvitamin D.
a Values are means ± SDs (range); n = 50.
b Blood samples were taken before hip fracture surgery (Pre-op) and collected again 2 to 4 days after surgery (Post-op).
c Paired t test for values pre- and postoperative.
d ANCOVA, analysis adjusted for age and BMI.