Figure 3.

Image processing sequence for feature tracking of the aorto-mitral apparatus ROIs. (A) Five exemplar frames out of a typical 24-frame three-chamber cine showing the four ROIs. Each ROI is separately tracked by a modified Kalman filter algorithm that handles CMR cine images (B) in MATLAB, from which the X/Y coordinates summarizing its path over 1 R–R interval (C) are then derived. The motion tracking algorithm operated on the three-chamber views and provided motion tracking coordinates in the two-dimensional space (X and Y, throughout the cardiac cycle). In these plots, all X/Y coordinate points were normalized to allow comparison across cohorts, and they are thus plotted on the X and Y axes accordingly. Abbreviations as in Figures 1 and 2.