Table 1.
Group Differences in BMI (Baseline and Five-year Change) and Demographics as a Function of APOE ε4 Carrier Status and Conversion to MCI or dementia.
| 2x2 Factorial ANOVA / Pearson χ2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ε4− | ε4+ | Conversion | APOE | Interaction | ||||||
| Variable | converters | nonconverters | converters | nonconverters | p | ES | p | ES | p | ES |
| N (Total = 1289) | 159 | 744 | 118 | 268 | ||||||
| Age, M (SD) | 74.3 (4.0) | 72.0 (4.5) | 73.1 (4.3) | 70.8 (4.2) | <.001 | −0.528 a | <.001 | 0.269 a | .937 | <.001b |
| Education, M (SD) | 15.8 (3.1) | 16.2 (3.0) | 16.2 (2.9) | 15.9 (2.9) | .811 | 0.017a | .636 | 0.033a | .121 | .002b |
| Sex, N (% Male) | 66 (41.5) | 246 (33.1) | 43 (36.4) | 88 (32.8) | .049 | .003 c | .832 | <.001c | - | - |
| Race, N (% White) | 145 (91.2) | 620 (83.3) | 104 (88.1) | 216 (80.6) | .003 | .007 c | .413 | <.001c | - | - |
| Baseline BMI (kg/m2), M (SD) | 26.6 (4.9) | 27.3 (5.2) | 26.8 (4.9) | 27.1 (5.0) | .335 | 0.069a | .974 | 0.002a | .392 | <.001b |
| ΔBMI, M (SD) | −0.03 (1.0) | 0.007 (1.0) | −0.3 (1.2) | 0.1 (0.9) | .066 | 0.136a | .168 | 0.101a | .034 d | .004 b |
Notes. ΔBMI = five-year age- and education-adjusted standardized residualized change (z-score units); Baseline BMI adjusted for age and education; ES = effect size: aCohen's d, bpartial eta2, and cphi2. dFollow-up Games-Howell analyses of simple effects showed the interaction was due to a greater decline in BMI for carriers who converted to MCI/AD vs. carriers who did not convert, p = .006, d = .34 rather than for noncarriers who converted vs. noncarriers who did not convert, p = .65, d = 0.02.