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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1996 Apr;60(4):428–430. doi: 10.1136/jnnp.60.4.428

Non-ketotic hyperglycaemic chorea: a SPECT study.

M H Chang 1, J Y Li 1, S R Lee 1, C Y Men 1
PMCID: PMC1073898  PMID: 8774410

Abstract

OBJECTIVE: To study regional blood flow of the striatum in non-ketotic hyperglycaemic choreic patients. METHODS: Brain SPECT was performed with intravenous injection of 20 mCi 99mTc hexamethylpropylene amineoxime in six non-ketotic hyperglycaemic choreic patients and 10 age matched patients with a similar level of hyperglycaemia without chorea as a control. The focal perfusion defects were analysed by visual interpretation and semiquantitative determination with reference to homolateral occipital blood flow. RESULTS: The measured blood flow of striatum on the contralateral side of chorea was significantly decreased. CONCLUSIONS: Hypometabolism of the striatum is seen not only in Huntington's disease, but also in non-ketotic hyperglycaemic chorea. Hypofunction of the striatum is a possible common pathogenesis in the development of contralateral chorea in different diseases. Furthermore, the sensitivity and reliability of SPECT is as good as PET in assessing choreic patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEDWELL S. F. Some observations on hemiballismus. Neurology. 1960 Jun;10:619–622. doi: 10.1212/wnl.10.6.619. [DOI] [PubMed] [Google Scholar]
  2. Dewey R. B., Jr, Jankovic J. Hemiballism-hemichorea. Clinical and pharmacologic findings in 21 patients. Arch Neurol. 1989 Aug;46(8):862–867. doi: 10.1001/archneur.1989.00520440044020. [DOI] [PubMed] [Google Scholar]
  3. HYLAND H. H., FORMAN D. M. Prognosis in hemiballismus. Neurology. 1957 Jun;7(6):381–391. doi: 10.1212/wnl.7.6.381. [DOI] [PubMed] [Google Scholar]
  4. Hammond S. R., English D. R., de Wytt C., Hallpike J. F., Millingen K. S., Stewart-Wynne E. G., McLeod J. G., McCall M. G. The contribution of mortality statistics to the study of multiple sclerosis in Australia. J Neurol Neurosurg Psychiatry. 1989 Jan;52(1):1–7. doi: 10.1136/jnnp.52.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hosokawa S., Ichiya Y., Kuwabara Y., Ayabe Z., Mitsuo K., Goto I., Kato M. Positron emission tomography in cases of chorea with different underlying diseases. J Neurol Neurosurg Psychiatry. 1987 Oct;50(10):1284–1287. doi: 10.1136/jnnp.50.10.1284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jones H. R., Jr, Siekert R. G. Embolic mononeuropathy and bacterial endocarditis. Arch Neurol. 1968 Nov;19(5):535–537. doi: 10.1001/archneur.1968.00480050105010. [DOI] [PubMed] [Google Scholar]
  7. Kuwert T., Lange H. W., Langen K. J., Herzog H., Aulich A., Feinendegen L. E. Cortical and subcortical glucose consumption measured by PET in patients with Huntington's disease. Brain. 1990 Oct;113(Pt 5):1405–1423. doi: 10.1093/brain/113.5.1405. [DOI] [PubMed] [Google Scholar]
  8. Leenders K. L., Frackowiak R. S., Quinn N., Marsden C. D. Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomography. Mov Disord. 1986;1(1):69–77. doi: 10.1002/mds.870010110. [DOI] [PubMed] [Google Scholar]
  9. Lin J. J., Chang M. K. Hemiballism-hemichorea and non-ketotic hyperglycaemia. J Neurol Neurosurg Psychiatry. 1994 Jun;57(6):748–750. doi: 10.1136/jnnp.57.6.748. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Nabatame H., Nakamura K., Matsuda M., Fujimoto N., Shio H. Hemichorea in hyperglycemia associated with increased blood flow in the contralateral striatum and thalamus. Intern Med. 1994 Aug;33(8):472–475. doi: 10.2169/internalmedicine.33.472. [DOI] [PubMed] [Google Scholar]
  11. Otsuka M., Ichiya Y., Kuwabara Y., Hosokawa S., Sasaki M., Fukumura T., Masuda K., Goto I., Kato M. Cerebral glucose metabolism and striatal 18F-dopa uptake by PET in cases of chorea with or without dementia. J Neurol Sci. 1993 Apr;115(2):153–157. doi: 10.1016/0022-510x(93)90218-n. [DOI] [PubMed] [Google Scholar]
  12. Rector W. G., Jr, Herlong H. F., Moses H., 3rd Nonketotic hyperglycemia appearing as choreoathetosis or ballism. Arch Intern Med. 1982 Jan;142(1):154–155. [PubMed] [Google Scholar]
  13. Sanfield J. A., Finkel J., Lewis S., Rosen S. G. Alternating choreoathetosis associated with uncontrolled diabetes mellitus and basal ganglia calcification. Diabetes Care. 1986 Jan-Feb;9(1):100–101. doi: 10.2337/diacare.9.1.100b. [DOI] [PubMed] [Google Scholar]

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