TABLE 3.
One‐way repeated measures ANOVA analysis comparing patient‐reported outcome measures after 12 months in study participants (n = 68).
| PROM | Baseline | 1 month | 3 months | 6 months | 12 months | F‐value | p‐Value |
|---|---|---|---|---|---|---|---|
| GAD‐7 | 10.85 ± 5.91 | 6.72 ± 6.08 | 6.38 ± 5.33 | 6.88 ± 4.95 | 8.44 ± 5.87 | 11.594 | <0.001*** |
| SQS | 4.18 ± 2.34 | 5.75 ± 2.45 | 5.91 ± 2.55 | 6.07 ± 2.47 | 5.41 ± 2.91 | 11.049 | <0.001*** |
| EQ‐5D‐5L Mobility | 1.53 ± 0.94 | 1.50 ± 0.91 | 1.43 ± 0.82 | 1.51 ± 0.87 | 1.54 ± 0.92 | 2.502 | 0.051 |
| EQ‐5D‐5L Selfcare | 1.46 ± 0.85 | 1.44 ± 0.85 | 1.37 ± 0.73 | 1.43 ± 0.83 | 1.51 ± 0.89 | 1.480 | 0.219 |
| EQ‐5D‐5L Usual Activities | 2.09 ± 1.22 | 1.88 ± 1.78 | 1.72 ± 0.88 | 1.85 ± 1.00 | 2.01 ± 1.13 | 2.377 | 0.061 |
| EQ‐5D‐5L Pain and Discomfort | 2.13 ± 1.12 | 1.74 ± 1.05 | 1.71 ± 0.75 | 1.84 ± 0.91 | 2.00 ± 1.09 | 5.660 | <0.001*** |
| EQ‐5D‐5L Anxiety and Depression | 2.82 ± 1.09 | 2.40 ± 1.08 | 2.25 ± 1.04 | 2.38 ± 1.02 | 2.66 ± 1.13 | 6.930 | <0.001*** |
| EQ‐5D‐5L Index values | 0.60 ± 0.28 | 0.70 ± 0.29 | 0.73 ± 0.22 | 0.70 ± 0.23 | 0.63 ± 0.27 | 6.719 | <0.001*** |
| PGIC | – | 6.00 [5.00–6.00] | 6.00 [6.00–7.00] | 6.00 [5.00–7.00] | 6.00 [6.00–6.00] | – | – |
Note: Each patient‐reported outcome measure (PROM) is displayed in mean ± standard deviation (SD), except for PGIC which is presented as median [interquartile range, IQR].
Abbreviations: GAD‐7, generalized anxiety disorder‐7; PGIC, Patient Global Impression of Change; PROM, patient reported outcome measure; SD, standard deviation; SQS, Single‐Item Sleep Quality Scale.
*** p < 0.001.