TABLE 6.

One‐way ANOVA analysis comparing patient‐reported outcome measures (PROMs) at follow‐up intervals relative to baseline for each treatment type.

PROM	Follow‐up interval	Oils		Dried flower		Oils and dried flower		p‐Value
		Mean difference	SD	Mean difference	SD	Mean difference	SD
GAD‐7	1 month	1.41	4.08	3.00	5.34	2.35	4.85	<0.001***
GAD‐7	3 months	1.25	4.32	3.12	5.70	2.44	5.39	<0.001***
GAD‐7	6 months	1.20	4.47	3.22	5.72	2.50	5.60	<0.001***
GAD‐7	12 months	1.15	4.43	3.49	5.98	2.48	5.56	<0.001***
SQS	1 month	−0.92	2.36	−1.57	2.42	−1.43	2.58	<0.001***
SQS	3 months	−1.04	2.40	−1.62	2.53	−1.55	2.63	<0.001***
SQS	6 months	−0.97	2.47	−1.61	2.71	−1.61	2.63	<0.001***
SQS	12 months	−1.01	2.44	−1.55	2.86	−1.61	2.63	<0.001***
EQ‐5D‐5L mobility	1 month	0.10	0.68	0.13	0.68	0.16	0.74	0.347
EQ‐5D‐5L mobility	3 months	0.10	0.74	0.12	0.65	0.17	0.77	0.297
EQ‐5D‐5L mobility	6 months	0.09	0.75	0.11	0.79	0.21	0.83	0.021*
EQ‐5D‐5L mobility	12 months	0.06	0.77	0.07	0.82	0.20	0.81	0.012*
EQ‐5D‐5L self‐care	1 month	0.05	0.63	0.11	0.67	0.06	0.72	0.543
EQ‐5D‐5L self‐care	3 months	0.02	0.72	0.02	0.64	0.12	0.74	0.057
EQ‐5D‐5L self‐care	6 months	0.04	0.72	0.06	0.69	0.12	0.76	0.218
EQ‐5D‐5L self‐care	12 months	0.03	0.74	0.05	0.70	0.14	0.78	0.051
EQ‐5D‐5L usual activities	1 month	0.22	0.88	0.44	0.90	0.33	0.93	0.004**
EQ‐5D‐5L usual activities	3 months	0.22	0.92	0.42	0.93	0.34	1.00	0.009**
EQ‐5D‐5L usual activities	6 months	0.24	0.95	0.42	0.94	0.37	1.08	0.019*
EQ‐5D‐5L usual activities	12 months	0.19	0.91	0.40	1.00	0.34	1.02	0.004**
EQ‐5D‐5L pain and discomfort	1 month	0.31	0.85	0.50	0.91	0.52	0.91	<0.001***
EQ‐5D‐5L pain and discomfort	3 months	0.36	0.87	0.48	0.88	0.58	0.94	<0.001***
EQ‐5D‐5L pain and discomfort	6 months	0.35	0.85	0.54	0.94	0.56	0.94	<0.001***
EQ‐5D‐5L pain and discomfort	12 months	0.34	0.85	0.52	0.93	0.54	0.94	<0.001***
EQ‐5D‐5L anxiety and depression	1 month	0.18	0.79	0.44	0.89	0.36	0.87	<0.001***
EQ‐5D‐5L anxiety and depression	3 months	0.15	0.85	0.46	1.04	0.37	0.97	<0.001***
EQ‐5D‐5L anxiety and depression	6 months	0.16	0.85	0.46	1.02	0.39	1.02	<0.001***
EQ‐5D‐5L anxiety and depression	12 months	0.14	0.87	0.51	1.06	0.37	1.03	<0.001***
EQ‐5D‐5L index value	1 month	−0.08	0.20	−0.13	0.21	−0.12	0.23	<0.001***
EQ‐5D‐5L index value	3 months	−0.08	0.22	−0.12	0.21	−0.13	0.24	<0.001***
EQ‐5D‐5L index value	6 months	−0.08	0.22	−0.14	0.22	−0.14	0.26	<0.001***
EQ‐5D‐5L index value	12 months	−0.07	0.22	−0.14	0.23	−0.14	0.25	<0.001***

Note: A one‐way ANOVA compared the difference in means at follow‐up intervals relative to baseline for each treatment type to analyze differences between the route of administration and PROM scores in all patients treated with cannabis‐based medicinal products.

Abbreviations: GAD‐7, generalized anxiety disorder‐7; PROM, patient‐reported outcome measure; SD, standard deviation; SQS, Single‐Item Sleep Quality Scale.

^* p < 0.050;

^** p < 0.010;

^*** p < 0.001.