. 2023 Dec 6;43(4):616–632. doi: 10.1002/npr2.12403

TABLE 7.

Tukey's honestly significant difference test for statistically significant ANOVA outcomes.

PROM	Follow‐up interval	Oils vs dried flower			Oils vs oils and dried flower			Oils and dried flower vs dried flower
PROM	Follow‐up interval	Mean difference	95% confidence interval	p _adj	Mean difference	95% confidence interval	p _adj	Mean difference	95% confidence interval	p_adj
GAD‐7	1 month	1.58	[0.76–2.41]	<0.001***	0.94	[0.30–1.59]	0.002**	0.64	[−0.21–1.49]	0.185
GAD‐7	3 months	1.86	[0.97–2.76]	<0.001***	1.19	[0.49–1.88]	<0.001***	0.68	[−0.25–1.60]	0.197
GAD‐7	6 months	2.03	[1.11–2.95]	<0.001***	1.31	[0.59–2.03]	<0.001***	0.72	[−0.23–1.67]	0.177
GAD‐7	12 months	2.34	[1.42–3.26]	<0.001***	1.33	[0.61–2.05]	<0.001***	1.01	[0.05–1.96]	0.035*
SQS	1 month	−0.65	[−1.08 – −0.21]	0.002**	−0.51	[−0.86 – −0.17]	0.001**	−0.13	[−0.59–0.32]	0.780
SQS	3 months	−0.58	[−1.03 – −0.13]	0.007**	−0.51	[−0.86 – −0.15]	0.002**	−0.07	[−0.54–0.39]	0.930
SQS	6 months	−0.64	[−1.10 – −0.18]	0.003**	−0.64	[−1.00 – −0.28]	<0.001***	0.00	[−0.48–0.48]	1.000
SQS	12 months	−0.54	[−1.00 – −0.08]	0.017*	−0.60	[−0.97 – −0.24]	<0.001***	0.06	[−0.42–0.54]	0.950
EQ‐5D‐5L mobility	6 months	0.01	[−0.13–0.15]	0.969	0.12	[0.01–0.23]	0.03*	−0.10	[−0.25–0.04]	0.210
EQ‐5D‐5L mobility	12 months	0.01	[−0.13–0.15]	0.985	0.13	[0.02–0.25]	0.012*	−0.12	[−0.27–0.02]	0.114
EQ‐5D‐5L usual activities	1 month	0.22	[0.06–0.38]	0.004**	0.11	[−0.02–0.23]	0.109	0.11	[−0.06–0.28]	0.261
EQ‐5D‐5L usual activities	3 months	0.20	[0.03–0.37]	0.014*	0.12	[−0.01–0.26]	0.073	0.08	[−0.10–0.26]	0.548
EQ‐5D‐5L usual activities	6 months	0.18	[0.00–0.36]	0.046*	0.13	[−0.01–0.27]	0.068	0.05	[−0.14–0.23]	0.810
EQ‐5D‐5L usual activities	12 months	0.21	[0.04–0.38]	0.012*	0.15	[0.02–0.29]	0.022*	0.06	[−0.12–0.24]	0.736
EQ‐5D‐5L pain and discomfort	1 month	0.19	[0.03–0.35]	0.012*	0.21	[0.08–0.33]	<0.001***	−0.02	[−0.18–0.15]	0.972
EQ‐5D‐5L pain and discomfort	3 months	0.12	[−0.04–0.28]	0.180	0.23	[0.10–0.35]	<0.001***	−0.11	[−0.27–0.06]	0.285
EQ‐5D‐5L pain and discomfort	6 months	0.19	[0.03–0.35]	0.017*	0.21	[0.08–0.33]	<0.001***	−0.02	[−0.18–0.15]	0.968
EQ‐5D‐5L pain and discomfort	12 months	0.19	[0.03–0.35]	0.017*	0.20	[0.07–0.33]	<0.001***	−0.01	[−0.18–0.15]	0.983
EQ‐5D‐5L anxiety and depression	1 month	0.26	[0.11–0.41]	<0.001***	0.18	[0.06–0.29]	0.001**	0.08	[−0.07–0.24]	0.415
EQ‐5D‐5L anxiety and depression	3 months	0.32	[0.15–0.48]	<0.001***	0.22	[0.09–0.35]	<0.001***	0.09	[−0.08–0.26]	0.429
EQ‐5D‐5L anxiety and depression	6 months	0.30	[0.13–0.47]	<0.001***	0.23	[0.10–0.37]	<0.001***	0.07	[−0.11–0.24]	0.624
EQ‐5D‐5L anxiety and depression	12 months	0.37	[0.20–0.54]	<0.001***	0.23	[0.09–0.36]	<0.001***	0.14	[−0.04–0.32]	0.148
EQ‐5D‐5L index value	1 month	−0.05	[−0.09 – −0.01]	0.005**	−0.04	[−0.07 – −0.01]	0.002**	‐0.01	[−0.05–0.03]	0.906
EQ‐5D‐5L index value	3 months	−0.05	[−0.09 – −0.01]	0.023*	−0.05	[−0.09 – −0.02]	<0.001***	0.01	[−0.03–0.05]	0.858
EQ‐5D‐5L index value	6 months	−0.05	[−0.10 – −0.01]	0.007**	−0.05	[−0.09 – −0.02]	<0.001***	0.00	[−0.04–0.04]	0.998
EQ‐5D‐5L index value	12 months	−0.06	[−0.10 – −0.02]	0.002**	−0.06	[−0.09 – −0.03]	<0.001***	0.00	[−0.04–0.04]	0.998

Note: Tukey honestly significant difference post hoc test was conducted on the statistically significant mean differences identified from the one‐way ANOVA to determine statistically significant differences in outcome scores based on the type of cannabis‐based medicinal product patients received.

Abbreviations: GAD‐7, generalized anxiety disorder; p _adj, adjusted p‐value; PROM, patient‐reported outcome measure; SQS, Single‐Item Sleep Quality Scale.

p < 0.050;

^**

p < 0.010;

^***

p < 0.001.