Table I.
Species/cell | Approach | Main finding | Reference |
---|---|---|---|
Monkey/CVG-2 | Laser microsurgery | A bipolar mitotic spindle is formed in the absence of centrosomes. | Khodjakov et al., 2000 |
Fly | Mutant of DSas-4 | Centrosomes are not necessary for the development of the fly. | Basto et al., 2006 |
Monkey/BSC-1 | Needle microsurgery | The fidelity of the bipolar mitotic spindle is highly compromised in the absence of centrosomes. | Hornick et al., 2011 |
Chicken/DT40 | Knockout of CEP152/STIL | Centrosome loss leads to delays in spindle formation and high rates of chromosomal instability. | Sir et al., 2013 |