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. 2023 Dec 8;14:1287367. doi: 10.3389/fimmu.2023.1287367

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Copyright © 2023 Groth, Maric, Garcés Lázaro, Hofman, Zhang, Ni, Keller, Seufert, Hofmann, Neumann-Haefelin, Sticht, Rippe, Urban and Cerwenka

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NK cell phenotype in hepatitis patients. (A) Frequency of circulating CD3^-CD16⁺CD56^dim and CD3^-CD16^-CD56^bright NK cells in healthy donors (HD) (n=29), chronic hepatitis B/D (cHBV/cHDV) (n=5) and resolved cHBV/cHDV patients among PBMCs (n=9) (bars represent the mean frequency of cells +/- SEM). (B) Expression of CD69 or TRAIL on circulating CD3^-CD16⁺CD56^dim and CD3^-CD16^- CD56^bright NK cells in cHBV (n=12) and cHBV/cHDV (n=4) patients (bars represent the mean frequency of positive cells +/- SEM). Levels of significance: *p<0.05, **p<0.01, ****p<0.0001 (student’s t-test).