Table 3. Estimates of the Brain Incorporation Coefficient (K*).
K* (×10–3min–1) |
|||||
---|---|---|---|---|---|
methods | DHA probes | models | control | arecoline | ref |
autoradiography | 4,5-[3H]DHA | rats | 1.9 | 3.3 | (23) |
1-[14C]DHA | mice | 79.9–258.4 | 175.5–494.9 | (24) | |
1-[14C]DHA | rats | 13.9 | 23.3 | (27) | |
PET-MR | 1-[11C]DHA | humans | 4.0 | (33),(34) | |
22-[18F]FDHA | mice | 4.69 ± 1.09a | 12.20 ± 0.60a | this work |
Mean ± SD (n = 3).