. 2023 Dec 5;14(24):4383–4394. doi: 10.1021/acschemneuro.3c00717

Table 2. Diagnostic Accuracy Characteristics (AUC, S.E., Sensitivity, Specificity, PPV, NPV, Accuracy, and p Value) for GSH, GABA, Susceptibility, and Their Combined Effect in the SN and LH Regions To Differentiate HC and PD Groups.

test result variables	AUC[95% C.I.]	SE	sensitivity	specificity	PPV	NPV	accuracy	p-value
SN region
GSH	0.672[0.522–0.822]	0.077	0.591	0.710	0.617	0.688	0.658	0.035^a
GABA	0.544[0.390–0.698]	0.079	0.458	0.667	0.520	0.609	0.575	0.572
susceptibility	0.715[0.555–0.875]	0.082	0.786	0.583	0.705	0.682	0.696	0.019^a
GSH + susceptibility	0.836[0.705–0.966]	0.067	0.826	0.778	0.825	0.779	0.805	<0.0001^a
GSH + GABA + susceptibility	0.700[0.514–0.887]	0.095	0.864	0.857	0.885	0.833	0.861	0.029^a
LH region
GSH	0.709[0.538–0.880]	0.087	0.667	0.778	0.703	0.748	0.729	0.026^a
susceptibility	0.594[0.436–0.751]	0.080	0.583	0.679	0.589	0.674	0.637	0.248
GSH + susceptibility	0.744[0.565–0.923]	0.091	0.800	0.632	0.734	0.714	0.726	0.016^a

p < 0.05; statistically significant.