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. Author manuscript; available in PMC: 2025 Feb 1.
Published in final edited form as: Clin Neuropsychol. 2023 Jun 22;38(2):453–470. doi: 10.1080/13854046.2023.2223389

Table 3.

Linear regression models predicting left or right hippocampal volume, corrected for total intracranial volume.

Predictor Outcome Recency ratio Model1 Total ratio Model2 Immediate LMT Model3 Delayed LMT Model4
β p β p β p β p
Age at MRI scan Left HV −0.34 <.001 −0.33 <.001 −0.31 <.001 −0.29 <.001
Right HV −0.31 <.001 −0.30 <.001 −0.28 <.001 −0.26 <.001
Gender Left HV 0.30 <.001 0.31 <.001 0.30 <.001 0.28 <.001
Right HV 0.26 <.001 0.27 <.001 0.25 <.001 0.24 <.001
Education Left HV 0.07 .114 0.07 .105 0.05 .264 0.04 .343
Right HV 0.02 .613 0.02 .598 0.01 .923 0.00 .993
APOE risk score Left HV −0.08 .063 −0.08 .078 −0.06 .162 −0.05 .241
Right HV −0.04 .363 −0.04 .407 −0.02 .620 −0.02 .730
Elapsed time Left HV −0.05 .318 −0.07 .188 −0.05 .305 −0.06 .256
Right HV −0.06 .258 −0.07 .174 −0.06 .240 −0.07 .210
Sample Left HV 0.07 .226 0.08 .128 0.05 .379 0.03 .580
Right HV 0.13 .022 0.14 .012 0.11 .085 0.10 .111
LMT score Left HV −0.23 <.001* −0.25 <.001* 0.18 .002* 0.26 <.001*
Right HV −0.17 <.001* −0.19 <.001* 0.17 .004* 0.23 <.001*
AIC Left HV −837.50 −843.34 −820.72 −833.68
Right HV −818.49 −822.83 −814.68 −821.69
Adjusted R 2 Left HV .370 .380 .339 .363
Right HV .293 .302 .286 .300

Note: N = 355. β = Standardised regression coefficient; LMT = logical memory test; HV = Hippocampal volume; Elapsed time = time elapsed between MRI scan and neuropsychological assessment; p = p-value;

*

adjusted p-value for multiple comparisons. In all models, variables showed a Variation Inflation Factor (VIF) < 2; AIC = Akaike Information Criterion; Adjusted R2 = adjusted proportion of explained variance. Bold: model with significantly best model fit, as per delta-AIC. Models with left HV by TIV as outcome:

1

Model with Rr: F(7,347) = 30.644 p < .001;

2

Model with Tr: F(7,347) = 31.973 p < .001;

3

Model with Immediate LMT: F(7,347) = 26.940 p < .001;

4

Model with Delayed LMT: F(7,347) = 29.784 p < .001. With right HV by TIV as outcome:

1

Model with Rr: F(7,347) = 22.006 p < .001;

2

Model with Tr: F(7,347) = 22.888 p < .001;

3

Model with Immediate LMT: F(7,347) = 21.244 p < .001;

4

Model with Delayed LMT: F(7,347) = 22.655 p < .001.