Table 3.
Multivariate analyses of overall survival (OS) in the training datasets.
| Variables | β | HR (95%CI) | P-value |
|---|---|---|---|
| Age (years) | |||
| < 70 | Reference | ||
| ≥ 70 | 0.609 | 1.838 (1.440–2.397) | < 0.001 |
| Tumor location | < 0.001 | ||
| Right-sided colon | Reference | ||
| Left-sided colon | 0.249 | 1.282 (0.810–2.031) | 0.298 |
| Rectum | 0.730 | 2.074 (1.378–3.122) | < 0.001 |
| Differentiation status | 0.287 | ||
| Well | Reference | ||
| Moderate | -0.196 | 0.822 (0.555–1.218) | 0.329 |
| Poor | 0.157 | 1.170 (0.706–1.939) | 0.541 |
| Mucinous | -0.094 | 0.911 (0.519–1.598) | 0.744 |
| T stage | < 0.001 | ||
| Tis/T1 | Reference | ||
| T2 | 0.286 | 1.331 (0.699–2.532) | 0.384 |
| T3 | 0.847 | 2.334 (1.289–4.224) | 0.005 |
| T4 | 1.381 | 3.979 (1.997–7.930) | < 0.001 |
| N stage | < 0.001 | ||
| N0 | Reference | ||
| N1 | 0.601 | 1.825 (1.344–2.477) | < 0.001 |
| N2 | 1.248 | 3.484 (2.471–4.913) | < 0.001 |
| Preoperative CEA | |||
| < 2.9 ng/mL | Reference | ||
| ≥ 2.9 ng/mL | 0.191 | 1.210 (0.932–1.572) | 0.152 |
| Preoperative CA125 | |||
| < 13.4 U/mL | Reference | ||
| ≥ 13.4 U/mL | 0.363 | 1.437 (1.103–1.872) | 0.007 |
| Preoperative CA19-9 | |||
| < 10.1 U/mL | Reference | ||
| ≥ 10.1 U/mL | 0.396 | 1.486 (1.153–1.915) | 0.002 |
β, Beta; HR, Hazard Ratio; CI, Confidence Interval; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9; CA125, carbohydrate antigen 125.