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. 2023 Dec 21;6:1301. doi: 10.1038/s42003-023-05674-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a UMAP plot of single-cell transcriptome analysis, including PGCCs and non-PGCCs with and without Docetaxel treatment of three breast cancer cell lines (SUM159, MDA-MB-231, and Vari068). The x-axis represents UMAP1, the y-axis represents UMAP2, and each dot represents one cell. Different colors represent different cell populations/treatment conditions. Number of cells in each population were provided in the “Methods” section. b Comparison between altered genes in docetaxel-treated PGCCs vs. non-PGCCs of three breast cancer cell lines. c Top-ranked pathways (the KEGG 2021 Human and the NCI-Nature pathway databases) were determined by the altered genes of SUM159 PGCCs versus non-PGCCs. The x-axis and color represent the P-values, and the y-axis indicates the names of pathways. d Violin plots of docetaxel-treated SUM159 PGCCs and non-PGCCs cells with statistical tests. The y-axis represents gene expression with a logarithmic scale. Each dot represents one cell. * refers to P < 0.05. ** refers to P < 0.01, and *** refers to P < 0.001. e Treatment of Thiostrepton (FOXM1 inhibitor) at 4 concentrations (1 μM, 0.1 μM, 0,01 μM, and 0.001 μM) on SUM159 cells. The upper figure shows the treatment of cells without Docetaxel pre-treatment, and the lower figure shows the treatment of cells after Docetaxel pre-treatment. The x-axis represents the concentration of Thiostrepton. The left y-axis (black) represents the number of non-PGCCs, and the right y-axis (red) represents the number of PGCCs. The black curve indicates the number of non-PGCCs, and the red curve indicates the number of PGCCs. Error bars indicate the standard error of the mean (SEM), n = 4.