Table 1.
Demographic characteristics of pancreatic cancer (PaCa) cases and cancer-free controls.
| Characteristic Variables | Pancreatic Cancer (PaCa) Cases (n = 960) | Cancer-Free Controls (n = 257,348) | p-Value * |
|---|---|---|---|
| Gender | <0.001 | ||
| Woman | 442 (46.04%) | 134,552 (52.28%) | |
| Man | 518 (53.96%) | 122,796 (47.72%) | |
| Age # | 61.60 | 56.03 | <0.001 |
| Polygenic score (PRS) #(con) | |||
| Standardized PRS | 6.12 | 5.84 | <0.001 |
| Polygenic score (PRS) (cat) | <0.001 | ||
| Q1 | 135 (14.06%) | 51,469 (20%) | |
| Q2 | 141 (14.69%) | 51,470 (20%) | |
| Q3 | 168 (17.50%) | 51,469 (20%) | |
| Q4 | 234 (24.38%) | 51,470 (20%) | |
| Q5 | 282 (29.38%) | 51,470 (20%) | |
| Blood type | <0.001 | ||
| O blood type | 355 (36.98%) | 112,083 (43.55%) | |
| Non-O blood type | 605 (63.02%) | 145,265 (56.45%) | |
| Family history of bowel cancer | 0.255 | ||
| No | 858 (89.38%) | 232,791 (90.46%) | |
| Yes | 102 (10.63%) | 24,557 (9.54%) | |
| Tobacco smoking status | <0.001 | ||
| Never | 441 (45.94%) | 143,911 (55.92%) | |
| Previous | 373 (38.85%) | 87,948 (34.17%) | |
| Current | 146 (15.21%) | 25,489 (9.90%) | |
| Alcohol consumption amount | 0.192 | ||
| Never | 226 (23.54%) | 57,662 (22.41%) | |
| Men: >0–≤28 g/d, Women: >0–≤14 g/d | 347 (36.15%) | 100,383 (39.01%) | |
| Men: >28 g/d, Women: >14 g/d | 387 (40.31%) | 99,303 (38.59%) | |
| Physical activity (MET-min/week) a | 0.012 | ||
| <600 | 206 (21.46%) | 47,721 (18.54%) | |
| 600–3000 | 444 (46.25%) | 130,485 (50.70%) | |
| >3000 | 310 (32.29%) | 79,142 (30.75%) | |
| BMI | <0.001 | ||
| Normal or underweight (BMI < 25) | 249 (25.94%) | 85,040 (33.04%) | |
| Overweight (25 ≤ BMI < 30) | 421 (43.85%) | 109,575 (42.58%) | |
| Obese (BMI ≥ 30) | 290 (30.21%) | 62,733 (24.38%) | |
| Waist–hip ratio (WHR) | <0.001 | ||
| Normal (Men: <0.90, Women: <0.85) | 372 (38.75%) | 131,445 (51.08%) | |
| Abdominal obesity (Men: ≥0.90, Women: ≥0.85) | 588 (61.25%) | 125,903 (48.92%) | |
| Medical history-related variables | |||
| Pancreatitis | <0.001 | ||
| No | 888 (92.05%) | 254,962 (99.07%) | |
| Yes | 72 (7.5%) | 2386 (0.93%) | |
| Diabetes mellitus | <0.001 | ||
| No | 713 (74.27%) | 235,818 (91.63%) | |
| Yes | 247 (25.73%) | 21,530 (8.37%) | |
| Hepatitis B | 0.374 | ||
| No | 960 (100%) | 257,136 (99.92%) | |
| Yes | 0 (0%) | 212 (0.08%) | |
| Cholecystitis/cholelithiasis/cholecystectomy | <0.001 | ||
| No | 761 (79.27%) | 237,575 (92.32%) | |
| Yes | 199 (20.73%) | 19,773 (7.68%) | |
| Helicobacter pylori infection | 0.229 | ||
| No | 949 (98.85%) | 255,291 (99.20%) | |
| Yes | 11 (1.15%) | 2057 (0.80%) | |
| Systemic lupus erythematosus (SLE) | 0.607 | ||
| No | 959 (99.90%) | 256,902 (99.83%) | |
| Yes | 1 (0.10%) | 446 (0.17%) | |
| Vitamin D deficiency | |||
| No | 951 (99.06%) | 255,368 (99.23%) | 0.552 |
| Yes | 9 (0.94%) | 1980 (0.77%) | |
| Peritonitis | 0.157 | ||
| No | 959 (99.90%) | 256,349 (99.61%) | |
| Yes | 1 (0.10%) | 999 (0.39%) |
# Mean value; * Chi-square test statistic or Student’s t-test for mean values; a 600 MET-min/week = 150 min/week; 3000 MET-min/week = 750 min/week.