Table 3.
IC50 neutralization of each F(ab′)2 preparation against different variants.
| F(ab′)2 Preparation 1 |
Ancestral | P1 | Variant Delta |
Mu | Omicron |
|---|---|---|---|---|---|
| 001 | <1/50 2 | <1/50 | <1/50 | <1/50 | <1/50 |
| 002 | 1/533 | 1/339 | 1/318 | 1/181 | 1/123 |
| 003 | 1/18,528 | 1/12,364 | 1/10,071 | 1/7,113 | 1/3,918 |
| 003 (µg/mL) 3 | 0.64 | 0.96 | 1.18 | 1.67 | 3.04 |
1 Each F(ab′)2 preparation was from equine sera after 3 (001), 5 (002), and 9 (003) immunizations with the RBD of SARS-CoV-2, as described in Table 1. 2 Titers correspond to the dilution of the preparation causing a reduction of 50% in the number of lytic plaques. Each titer was obtained by logistic regression of the average of 3 replicas and is the geometric mean value of two independent experiments. 3 Protein concentration of the preparation 003 able to reduce 50% of the lytic plaques.