Table 5.
Longitudinal analysis of bacterial species, fraction of lifespan and CADES. Bacterial species identified as statistically significant using the Negative Binomial Mixed Model. FoL: Fraction of Lifespan. CADES; Canine Dementia Scale. Three different models are included, one each for FoL and CADES and a third in which both FoL and CADES were included. Lactobacillus gasseri is significantly associated with FoL when considered alone or with CADES in the model, and Leptotrichia sp. are significant associated with CADES when modeled without FoL. Statistically significant adjusted p values are in bold.
| Intercept | FoL | CADES | Pool | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Model | Taxa | Coefficient | adj. p-Value | Coefficient | adj. p-Value | Coefficient | adj. p-Value | Coefficient | adj. p-Value |
| FoL + Pool | Lactobacillus gasseri | 14.6450 | 2.4732 × 10−7 | 3.8586 | 0.0006 | NA | NA | 1.9296 | 0.5512 |
| CADES + Pool | Leptotrichia sp. oral taxon 212 | −9.2808 | 2.6547 × 10−16 | NA | NA | 2.2553 | 2.9289 × 10−5 | −0.5853 | 0.3086 |
| FoL + CADES + Pool | Leptotrichia sp. oral taxon 212 | −10.1695 | 3.8961 × 10−14 | −0.2427 | 0.9283 | 0.9270 | 0.3838 | −0.6415 | 0.5627 |
| Lactobacillus gasseri | −15.0134 | 2.0346 × 10−6 | 3.3870 | 0.0001 | 1.4296 | 0.2999 | 2.2378 | 0.5627 | |