Figure 2.

The effects of BPE administration on general locomotion and emotionality—like behavior in open-field test (OFT). BPE administration tended to improve general locomotion and emotionality, like behavior, but without any statistical significance (p > 0.05) (A–H). Each group consisted of 7 rats. The effects of BPE administration on spontaneous alternations in the Y-maze test are illustrated in Figure 3. Spontaneous alternation behavior tests measure the spatial working memory of rodents, which is a form of short-term memory; therefore, we evaluated the effects of BPE on the memory deficits induced by the Aβ_1-42 injection. Thus, the Aβ_1-42 group exhibited a significantly higher number of errors in the Y-maze test than the control group (p < 0.05). Conversely, BPE administration significantly reversed the impairment of spontaneous alternation behavior (p < 0.001).