Table A4.
Descriptive statistics of the patients used for the external validation. Values are presented as number (%) of patients or the median (IQR). day of start antibiotic therapy on the ICU (d0).
| Variables | Target Attained (N = 78) |
Target Not Attained (N = 72) |
Overall (N = 150) |
p-Value |
|---|---|---|---|---|
| Sex (male) | 47 (60.3%) | 50 (69.4%) | 97 (64.7%) | 0.315 |
| Age (years) | 64.0 [56.3, 73.0] | 59.0 [49.8, 68.3] | 62.0 [54.0, 70.0] | 0.013 |
| Study antibiotic | ||||
| Amoxicillin | 0 (0%) | 9 (12.5%) | 9 (6.0%) | 0.001 |
| Ceftazidime | 4 (5.1%) | 2 (2.8%) | 6 (4.0%) | |
| Ceftriaxone | 17 (21.8%) | 4 (5.6%) | 21 (14.0%) | |
| Meropenem | 39 (50.0%) | 38 (52.8%) | 77 (51.3%) | |
| Piperacillin/tazobactam | 18 (23.1%) | 19 (26.4%) | 37 (24.7%) | |
| Serum creatinine d0 (mg/dL) | 0.940 [0.663, 1.26] | 0.680 [0.500, 0.845] | 0.770 [0.570, 1.04] | <0.001 |