Table A5.

Dose regimens of the antibiotics used for the external validation. The dose regimens are based on the transcription of the defined daily dosages of the beta-lactam antibiotics, into the prescribed dosages on the ICUs in the participating hospitals to establish the dose ranges in which the models are able to predict target non-attainment.

Type of Antibiotic	Median Dosage	Lower 95% CI Median Dosage	Upper 95% CI Median Dosage
Amoxicillin/clavulanic acid	1000/200 mg q6h	1000/200 mg q6h	1000/200 mg q4h
Ceftazidime	1000 mg q8h	1000 mg q8h	2000 mg q8h
Ceftriaxone	2000 mg q24h	2000 mg q24h	2000 mg q24h
Meropenem	1000 mg q8h	1000 mg q8h	1000 mg q8h
Piperacillin/tazobactam	4000/500 mg q8h	4000/500 mg q8h	4000/500 mg q8h