Table A8.
Detailed description of variables used for the development of the beta-lactam target non-attainment models. Body Mass index (BMI); intensive care unit (ICU); day of start antibiotic therapy on the ICU (d0); C reactive protein (CRP); white blood cells (WBC).
| Variables | |
|---|---|
| Age | On admission; in years |
| Height | On admission; in cm |
| Body weight | On admission; in kg |
| Sex | Male or female |
| BMI | On admission; weight/height2 in kg/cm2 |
| Cardiac surgery | Cardiac surgery related diagnosis on admission; yes or no |
| Trauma | Surgery related diagnosis on admission; yes or no |
| Type of antibiotic | ceftriaxone was used as reference drug in comparison with the other beta-lactam antibiotics for target attainment because this was the most used antibiotic drug |
| The number of days in the ICU before start of the antibiotic | The number of days in the ICU from admission to d0 |
| Fluid balance | The amount of volume administered to the patient minus the excreted volume on d0 |
| Creatinine | Serum creatinine on d0; in mg/dL |
| Urea | Serum urea on d0; in mmol/L |
| CRP | Serum CRP on d0; in mg/L |
| WBC | Blood WBC on d0; in 109/L |
| Albumin | Serum albumin on d0; in mg/dL |