Figure 4.

Relative gene expression of List 2 proteins in public vascular datasets. (a) Relative gene expression of the 20 List 2 proteins in mouse cerebrovascular single cell transcriptome databases D1 [44] and D2 [31]. Abbreviations: EC, endothelial cell; aEC, arterial EC; capilEC, capillary EC; vEC, venular EC; vSMC, venular smooth muscle cell; aaSMC, arteriole SMC; aSMC, arterial SMC; PC, pericyte; (b) Correlation between mouse and human relative gene expression of the 20 List 2 proteins in brain vascular endothelial cells. Upregulated and downregulated proteins are shown as closed and open symbols, respectively. Solid line represents the linear regression (Pearson r² = 0.64, p < 0.001) and dotted lines are 99% confidence bands.