Figure 1.

Possible model for synergistic antimicrobial activity of gut AMPs with conventional antibiotics. As per their membrane-acting properties, continuous pore formation and increased membrane permeabilization by AMPs allow more influx of antibiotics and AMPs which results in efficient bactericidal activity along with improved targeting of intracellular components such as transcription, protein synthesis machinery, and protein folding. Gut AMPs might also facilitate enhanced biofilm disruption and inhibition of spore formation when used in combination with antibiotics.