Table 1.
Summary of human studies with TERRA expression profile and dysregulation.
| Reference | Human Model | Study Design | Biological Sample | Method | Main Findings |
|---|---|---|---|---|---|
| Sampl S et al., 2012 [42] | Astrocytoma | Cancer tissue | Tissue | Real-Time PCR | Down-regulation |
| Vitelli V et al., 2018 [43] | Head and neck squamous cell carcinoma | Healthy tissue/Cancer tissue | Tissue | Real-Time PCR | Down-regulation |
| Adishesh M et al. 2020 [44] | Endometrial cancer | Healthy tissue/Cancer tissue | Endometrial biopsy | Real-Time PCR | Down-regulation |
| Bae SU et al., 2019 [45] | Colorectal cancer | Cancer tissue | Tissue | Real-Time PCR | Up-regulation |
| Storti CB et al., 2020 [46] | Non-small cell lung cancer | Healthy tissue/Cancer tissue | Tissue | Real-Time PCR | Up-regulation |
| Cao H et al., 2020 [47] | Hepatocellular carcinoma | Healthy tissue/Cancer tissue | Tissue | FISH | Down-regulation |
| Manganelli M et al., 2022 [48] | Hepatocellular carcinoma | Healthy tissue/Cancer tissue Case/Control | Tissue Plasma | Real-Time PCR | Down-regulation in tissue Up-regulation in plasma |
| Wang Z et al., 2015 [49] | Cancer | Case/Control | Plasma | RNA Seq | Up-regulation |
| Gao Y et al., 2017 [50] | Idiopathic pulmonary fibrosis | Case/Control | Blood | Real-Time PCR | Up-regulation |
| Diman A et al., 2016 [51] | Healthy runners | Pre/post exercise tissue | Muscle biopsy | FISH | Up-regulation |
| Chang KV et al., 2020 [52] | Sarcopenia | Case/Control | Leukocytes | Real-Time PCR | Down-regulation |