Figure 2.

Regulation of the SREBP pathway in liver diseases. Hepatocarcinogenesis involves several stages, progressing through NAFL and NASH. Although progression is slow and partially reversible, the transition from NASH to HCC is irreversible. The SREBP pathway coordinates numerous signaling factors, such as the AKT–mTOR pathway and ER stress. These pathways regulate the different stages of cancer progression. Please refer to the list of abbreviations for the abbreviations mentioned in this figure.