Skip to main content
. 2023 Dec 12;11(12):3280. doi: 10.3390/biomedicines11123280
SREBPs sterol regulatory element-binding proteins
NAFLD nonalcoholic fatty liver disease
NASH non-alcoholic steatohepatitis
HCC hepatocellular carcinoma
MASLD metabolic dysfunction-associated liver disease
MASH metabolic dysfunction-associated steatohepatitis
ER endoplasmic reticulum
TG triglycerides
FAs fatty acids
SCAP SREBP cleavage-activating protein
INSIGS insulin-induced genes
PI3K phosphatidylinositol 3-kinase
PKB protein kinase B
AKT protein kinase B
mTOR mammalian target of rapamycin
PPAR peroxisome proliferator-activated receptor gamma
PNPLA3 patatin-like phospholipase3
LDL low-density lipoprotein
miRNAs micro-RNAs
lncRNAs long non-coding RNAs
MCD methionine-choline-deficient
NEAT1 abundant transcript 1
HFD high-fat diet
ER stress endoplasmic reticulum stress
UPR unfolded protein response
GRP78 glucose-regulated protein 78
ACC1 lipogenic enzymes acetyl-CoA carboxylase 1
SCD1 stearoyl-CoA desaturase 1
S1P site 1 protease
ECM extracellular matrix
TGF-β transforming growth factor beta
BrD4 bromodomain protein 4
MAT2B methionine adenosyltransferase 2B
SPIN1 spindlin 1
HDGF hepatoma-derived growth factor
AATFs apoptosis-antagonizing transcription factors
ZHX2 zinc fingers and homeoboxes2
ACSL4 Acyl CoA synthetase 4
HDAC8 histone deacetylase 8
STAT5 transcription 5
FADS2 fatty acid desaturase 2
KLF10 Krüppel-like factor 10
SND-1 tudor domain-containing-1