SREBPs |
sterol regulatory element-binding proteins |
NAFLD |
nonalcoholic fatty liver disease |
NASH |
non-alcoholic steatohepatitis |
HCC |
hepatocellular carcinoma |
MASLD |
metabolic dysfunction-associated liver disease |
MASH |
metabolic dysfunction-associated steatohepatitis |
ER |
endoplasmic reticulum |
TG |
triglycerides |
FAs |
fatty acids |
SCAP |
SREBP cleavage-activating protein |
INSIGS |
insulin-induced genes |
PI3K |
phosphatidylinositol 3-kinase |
PKB |
protein kinase B |
AKT |
protein kinase B |
mTOR |
mammalian target of rapamycin |
PPAR |
peroxisome proliferator-activated receptor gamma |
PNPLA3 |
patatin-like phospholipase3 |
LDL |
low-density lipoprotein |
miRNAs |
micro-RNAs |
lncRNAs |
long non-coding RNAs |
MCD |
methionine-choline-deficient |
NEAT1 |
abundant transcript 1 |
HFD |
high-fat diet |
ER stress |
endoplasmic reticulum stress |
UPR |
unfolded protein response |
GRP78 |
glucose-regulated protein 78 |
ACC1 |
lipogenic enzymes acetyl-CoA carboxylase 1 |
SCD1 |
stearoyl-CoA desaturase 1 |
S1P |
site 1 protease |
ECM |
extracellular matrix |
TGF-β |
transforming growth factor beta |
BrD4 |
bromodomain protein 4 |
MAT2B |
methionine adenosyltransferase 2B |
SPIN1 |
spindlin 1 |
HDGF |
hepatoma-derived growth factor |
AATFs |
apoptosis-antagonizing transcription factors |
ZHX2 |
zinc fingers and homeoboxes2 |
ACSL4 |
Acyl CoA synthetase 4 |
HDAC8 |
histone deacetylase 8 |
STAT5 |
transcription 5 |
FADS2 |
fatty acid desaturase 2 |
KLF10 |
Krüppel-like factor 10 |
SND-1 |
tudor domain-containing-1 |