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. 2023 Dec 20;64(15):24. doi: 10.1167/iovs.64.15.24

Figure 4.

Figure 4.

TRPM8 knockdown resulted in upregulated chemokine expression in mice after infection. (A–D) The gene expression of chemokine Ccl2, Ccl3, Cxcl1, Cxcl2 in cornea homogenates of WT mice and TRPM8−/− mice three days after HSV-1 infection or in mock-infected mice. Results are from one of three independent experiments (n = 3 mice per group). *P < 0.05, **P < 0.01. (E, F) The gene expression of cytokine IL-1β and IL-6 in cornea homogenates of WT mice and TRPM8−/− mice three days after HSV-1 infection or in mock-infected mice. Data from one of three independent experiments are the mean ± SEM (n = 3 mice per group). *P < 0.05. ***P < 0.001.