Figure 5.

TRPM8^−/− mice had an increased viral burden. (A) Representative result (left panel; 3 dpi) and statistical analysis (right panel; 1, 3, 6 dpi) of a plaque assay. The viral samples originated from WT mice (top line) and TRPM8^−/− mice (bottom line) and were diluted ×4, ×40, and ×400. Results are from one of three independent experiments (n = 4 mice per group). *P < 0.05. (B) Representative pictures of corneal HSV-1 fluorescein staining. (C) Copies of TK, VP16, and ICP0 in cornea samples were measured by qPCR. Rpl5 was used as the reference gene. Results are from one of three independent experiments (n = 4 mice per group). ***P < 0.001.