Table 2.
Recent ongoing clinical trials investigating FMT and probiotic supplementation in NAFLD/NASH.
| Study Title | Conditions | Interventions | NCT Number |
|---|---|---|---|
| Intestinal microbiota transplantation for nonalcoholic fatty liver disease | NAFLD | Intestinal microbiota transplantation | NCT03648086 |
| The effect of consecutive fecal microbiota transplantation on NAFLD | NAFLD | Gut microbiota transplantation | NCT04465032 |
| A prospective, randomized, controlled pilot study to characterize the intestinal microbiome and to evaluate the safety and fecal microbiome changes following administration of lyophilized PRIM-DJ2727 given orally in subjects with non-alcoholic fatty liver disease | NAFLD with history of diabetes mellitus | PRIM-DJ2727 | NCT04371653 |
| To evaluate the beneficial effect of probiotics on NAFLD patients and the role of gut microbiota modulation | NAFLD | Probiotics | NCT05402449 |
| Impact of FMT on the phenome in patients with NAFLD and fibrosis | NAFLD | FMT | NCT06024681 |
| Probiotics in NASH patients—PROBILIVER TRIAL | NAFLD | Probiotics | NCT03467282 |
| Fecal microbiota transplantation for the treatment of non-alcoholic steatohepatitis | NAFLD | FMT | NCT03803540 |
| Interest in “Combo” (a combination of dietary supplements including probiotics) in NASH improvement | NASH | Treatment with Combo (dietary supplements including probiotics) | NCT04781933 |
| Effects of Bacillus coagulans on liver and gut microbiota function in NAFLD | NAFLD | Bacillus coagulans | NCT05635474 |
| Effects of fecal microbiota transplantation on weight in obese patients with NAFLD | NAFLD | Diet/FMT/physical activity | NCT04594954 |
| Soluble fiber supplementation in NAFLD | NAFLD | Fructo-oligosaccharide-enriched inulin supplement | NCT05480696 |
| MLCT Oil for fatty liver—PASS Trial | NAFLD | MLCT Oil/LCT Oil | NCT05217745 |
| The effect of probiotics on the clinical outcomes and gut microenvironment in patients with fatty liver | NAFLD | Probiotics (microbial cell preparation) | NCT04074889 |
| Effect of probiotics or berberine in hepatic steatosis markers, cardiometabolic and microbiotic profile in NAFL. | NAFLD/obesity | Probiotics/berberine/probiotics and berberine | NCT05523024 |
| Nutraceutical improvement of glucose metabolism, NAFLD and insulin resistance by oat-fiber supplementation in Type 2 diabetes mellitus patients | Type 2 diabetes/NAFLD | Drinking powder supplement | NCT05654805 |
| Synbiotics and fecal microbiota transplantation to treat non-alcoholic steatohepatitis | NASH/NAFLD | Combination product: LFMT | NCT05821010 |
Data accessed at https://clinicaltrials.gov, on 17 October 2023.