Table 1.
Significant risk and protective factors for male seasonality, female seasonality, and female seasonal affective disorder (p < 0.05). Univariate and multivariate linear and logistic regression were performed for genotypic features in association with male and female seasonality (SPAQ M and F), while univariate and multivariate logistic regression were performed for female seasonal affective disorder (SAD F). Results from each separate analysis are grouped by outcome variable (SPAQ M, SPAQ F, SAD F), and univariate logistic odds ratios are enclosed in asterisks (risk factor: *odds ratio* > 1), multivariate linear estimates appear in brackets (risk factor: [estimate] > 0), and multivariate logistic odds ratios appear as plain numbers (risk factor: odds ratio > 1).
| Feature | Male | Female | |
|---|---|---|---|
| Risk | SPAQ M OR [estimate] | SPAQ F OR [estimate] | SAD F OR [estimate] |
| CLOCK3111-TC/ZBTB20-AT | 3.975 | ||
| CRY2-AA/PER3C-TG | [4.279] | ||
| CRY2-AA/VNTR-4,5 | *8.919* | ||
| PER2-GG/PER3B-AG | 7.262 | ||
| Anxiety | 1.061 | ||
| Evening type | *1.783* | ||
| Increasing Age | *6.406* | ||
| Sleep Disturbance | [0.320] | [0.173] | |
| Protective | |||
| VNTR-4,5 | 0.258 | ||
| CLOCK3111-TC/PER3B-GG | 0.357 | ||
| CLOCK3111-TC/PER3C-TT | 0.383 | ||
| CRY1-GG | 0.491 | ||
| CRY1-GG/PER2-AA | [−3.595] | ||
| CRY1-GG/VNTR-5,5 | *0.112* | ||
| CRY1-GG/ZBTB20-AA | 0.454 | ||
| PER2-AA/PER3C-TT | *0.203* | ||
| PER3B-GG/VNTR-4,5 | 0.304 | ||
| PER3C-TT/VNTR-4,5 | 0.361 | ||
| VNTR-4,5/ZBTB20-AA | 0.321 | ||
| Morning type | 0.937 | ||