Figure 1.
AKT-1005 treatment caused vascular relaxation in third-order mesenteric arteries of CD1 non-pregnant control mice. (a) Dose–response curve of third-order mesenteric arteries from CD1 non-pregnant mice were used for wire-myography studies. Percentage of vasorelaxation shown on phenylephrine contracted vessels, as analyzed in intact arterial rings. n = 8 vessels from 5 mice/group. Mean ± SEM. Repeated-measures ANOVA: *: p < 0.05, **: p < 0.01, ***: p < 0.001. % vasorelaxation with (b,c) 3 × 10−6 M/L and (c) 3 × 10−5 M/L AKT-1005 is shown on phenylephrine-contracted vessels. n = 8 vessels from 5 mice/group. Mean ± SEM. Unpaired t-test: **: p < 0.01, ***: p < 0.001.