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. 2023 Nov 23;12(12):2036. doi: 10.3390/antiox12122036

Figure 5.

Figure 5

AKT-1005 treatment reduced both placental and systemic expression of sEndoglin protein (anti-angiogenic response) in Ad.sFlt-1-injected CD1 pregnant mice. (a) Quantitation of placental sEng expression: mean optical density was calculated in 5 high-power fields per sample (n = 3 per group). (b) Serum sEng expression was normalized to total protein concentrations in the plasma (n = 13). Kruskal-Wallis test, Dunn’s post-hoc test, Median [IQR], Control vs. Vehicle + Ad.sFlt-1: ****: p < 0.0001, Vehicle + Ad.sFlt-1 vs. AKT-1005 + Ad.sFlt-1: *: p < 0.1, **: p < 0.01, Control vs. AKT-1005 + Ad.sFlt-1: ***: p < 0.001.