Figure 6.

Pregnancy outcomes were not altered by AKT-1005 treatment. Mice were given Ad.sFlt-1 at gd8, and then, treated with 20 mg/kg/day of AKT-1005 via minipump from gd11. Tissue was collected at gd17. (a) Embryo weight, (b) placenta weight, (c) number of embryos and (d) placental/embryo weights were measured. No significant difference was found between AKT-1005- and vehicle- treated groups at gd17. All data are mean ± SEM, analyzed via unpaired 2-tailed t test with Welch’s correction, except H. Unless specified, n = 18 control and n = 20 AKT-1005-treated mice.