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. 2023 Nov 21;96(3):1253–1265. doi: 10.3233/JAD-230581

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© 2023 – The authors. Published by IOS Press

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Correlations between oral parameters and PET tracer retention. A) T-score maps of correlation analyses between the number of remaining teeth and each PET tracer retention in HCs and AD-spectrum patients. B) T-score maps of correlation analyses between periodontal status (BGI index) and each PET tracer retention in HCs and AD-spectrum patients. Regions with significant correlations indicated an increase of tau PET tracer accumulation with a decrease in the number of remaining teeth (uncorrected, p < 0.05). The cluster size threshold was set to the expected voxel of each analysis. Results were expressed in the MNI coordinate space. AD, Alzheimer’s disease; BGI, biofilm–gingival interface; HCs, healthy controls; MNI, Montreal Neurological Institute; PET, positron emission tomography.