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Analysis of interactions of native CYP107A1 (A) and mutant CYP107A1 (A245S) (B) bound with ketoconazole. Amino acids within 5 Å are shown in cyan. Substituted amino acid (Ala and Ser) is colored orange. Heme is shown in green, and substrate is shown in blue. Amino acid residues are labelled according to their one-letter code. PDB code is within brackets next to the respective P450 name. A list of all amino acid residues shown in this figure is represented in Table 5.
