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. 2023 Dec 1;13(12):1733. doi: 10.3390/biom13121733

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Analysis of the effect of Ala-245 substitution on the interactions of CYP107A1 with 6-deoxyerythronolide B (6-DEB). Interactions of 6-DEB with Native (A), A245S (B), and A245T (C) CYP107A1 are shown in the figure. Amino acids within 5 Å are shown in cyan. Substituted amino acid is colored orange. Dioxygen is shown as magenta, and water molecules as red spheres. Heme is shown in green, and substrate is shown in blue. Polar interactions are shown as red dashed lines. Amino acid residues are labelled according to their one-letter code. PDB code is displayed within brackets next to the respective P450 name. A list of all amino acid residues shown in this figure is represented in Table 5.