Figure 5.

(A–F) Sesamin’s effects on liver histopathology against cyclophosphamide by using hamtoxylin and esosin (H&E) stain. (A) Control represents the normal histology without any changes with an injury score of 0. (B) Cyclophosphamide represents a clear abnormality such as inflammation, necrosis, and sinusoidal disturbances with an injury score of 4. (C,D) Cyclophosphamide + sesamin represents both doses (20 and 10 mg/kg) of sesamin treatment and recovery with injury scores of 2 and 3, respectively. (E) Sesamin 20 represents the alone treatment without any alteration with an injury score of 0. The effectiveness of sesamin against cyclophosphamide represented the hepatic injury score in figure (F). Cyclophosphamide vs. control is highly significant (**** p < 0.0001); sesamin 20 vs. control is not significant (^ns p > 0.05); and sesamin 20 and 10 + cyclophosphamide vs. cyclophosphamide is a significant restore (** p < 0.001, **** p < 0.0001). Arrows indicate the sinusoidal disturbances in the above pictures.